SKU: 33697896213

Chiral Photochemical Scissors Targeting Proteins

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Description

Chiral Photochemical Scissors Targeting ProteinsThe remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction. Some factors that impact the photocleavage

The remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction. Some factors that impact the photocleavage reaction include the exact location of the probe binding site on the protein, conformations of the bound probe at the binding site, protein size, functional groups present on the probe that interact with the protein surroundings either in a favorable or unfavorable manner, overall charge on the photoreagent, and photophysical as well as photochemical properties of the probe. The protein photocleavage studies, in all case, were preceded by detailed binding studies by a variety of spectroscopic methods. Methods as simple as absorption and fluorescence spectroscopies or more sophisticated circular dichroism spectroscopy were used. Conclusions that are most consistent with the binding data indicated a single binding site on most proteins, irrespective of the probe or the protein, with only one exception noted so far. Photoactivation of the bound probe resulted in protein cleavage at a single site, in many instances. The specificity for the reaction has been investigated in detail and molecular modeling studies provided a firm ground to rationalize the observed cleavage sites. The reagents provide unique tools for sequencing large proteins by converting them into smaller fragments by non-biochemical transformations. Understanding of the rules for the above methodology are also investigated which provided rational methods for the design of small molecules that could bind at particular sites on large proteins, and this is a major breakthrough for a variety of fields including drug design, protein targeting, mass spectrometry, proteomics and other cutting-edge research areas.

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SKU: 33697896213

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John O.
Bozeman, US
★★★★★ 5
Does the job
Color: Mattle Black
Kinda cool and does the job and cheap. Nice product
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Reviewed in the United States on April 2, 2026
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B. Naranjo
Alexandria, US
★★★★★ 4
works well and sturdy
Color: Silver
work well, keep my sink from getting "slimy" corners and soap buildup
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Reviewed in the United States on May 27, 2026
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DHB
Carnegie, US
★★★★★ 5
Perfect for your sink organization
Color: Silver Grey
I have searched many sites for a product that will fit on our sink for all our kitchen and dishwashing needs and I finally found this product which proper fits with our kitchen decor and fits perfectly on our sink and it is very strong. I’m not worried about it breaking it anyway. Well with the price.
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Reviewed in the United States on May 24, 2026
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Adam
Grantham, US
★★★★★ 5
Love it
Color: Mattle Black
We'd been looking for a sponge holder we liked for a while andy wife came across this one. We were not disappointed. It's plenty big to hold a handful of sponges and scrubbers, plus our hand soap. I like the design that lets excess water drip back into the sink. Looks pretty low profile and sleek too
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Reviewed in the United States on May 18, 2026
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Cathy
Bozeman, US
★★★★★ 5
Keeps the water off your counter!
Color: Mattle Black, Color: Mattle Black
Works great! I’ve been looking for a solution to stop the sponge water from spilling onto the counter! Liked nice and neat. Great for keeping everything neat and organized. Size is perfect for sponges and nail brush and a small soap bottle.
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Reviewed in the United States on November 2, 2025

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