DMSA Coated Fe3O4 Nanoparticles

DMSA Coated Fe3O4 NanoparticlesProduct Name DMSA coated Fe3O4 nanoparticles (High temperature Pyrolysis Method) Product Overview Carboxylated Fe3O4 nanoparticles (high temperature pyrolysis method) are obtained by modifying DMSA with XFJ67 to obtain carboxyl groups, converting oil soluble nanoparticles into water soluble nanoparticles, which are more suitable for applications in the biological field. Technical Parameter Form: Brown black clear water colloid Fe concentration: about

Product Name

DMSA coated Fe3O4 nanoparticles (High-temperature Pyrolysis Method)

^{Product Overview}

Carboxylated Fe3O4 nanoparticles (high-temperature pyrolysis method) are obtained by modifying DMSA with XFJ67 to obtain carboxyl groups, converting oil soluble nanoparticles into water-soluble nanoparticles, which are more suitable for applications in the biological field.

^{Technical Parameter}

Form: Brown black clear water colloid

Fe concentration: about 4 mg/mL

Particle diameter:~5, 10, 20, 30, 50 nm (TEM) optional

Note: There are slight fluctuations in diameter and concentration between batches.

Note: Magnetic separation columns are required to achieve magnetic separation below 10nm

20nm can be separated by long-term magnetic attraction (the effect is not good, please use a magnetic separation column for complete separation)

Directly magnetically attracted above 30nm

50nm is prone to precipitation and requires ultrasonic treatment before use.

^{Product Features}

High surface negative charge: DMSA molecules form stable covalent bonds with the surface of Fe3O4 nanoparticles through their thiol groups, forming a thick molecular coating layer that imparts high surface negative charge to the nanoparticles.

Hydrophilicity: Fe3O4 nanoparticles modified with DMSA have good hydrophilicity and can maintain stability over a wide pH range.

Stability and dispersibility: DMSA modified Fe3O4 nanoparticles exhibit good dispersibility and stability, making them suitable for biomedical applications.

Can be used for biomolecule coupling: Due to the carboxyl groups on the surface, DMSA modified Fe3O4 nanoparticles can be used for biomolecule coupling and fixation, constructing nanoprobes.

Application Fields

Biomedical applications: Fe3O4 nanoparticles modified with DMSA can serve as drug carriers for targeted drug delivery and contrast enhancement in magnetic resonance imaging (MRI) due to their excellent biocompatibility and stability.

Magnetic hyperthermia (MHT): Under the action of an external alternating magnetic field, these nanoparticles can convert magnetic energy into thermal energy, which is used for magnetic hyperthermia treatment of tumors.

Gene therapy: DMSA modified Fe3O4 nanoparticles can be used as gene carriers for gene transfection and gene therapy.

Materials Science: In composite materials, Fe3O4 nanoparticles modified with DMSA can enhance the magnetic properties of the material, which can be used for the development of smart materials and sensors.

Biomolecular coupling: The carboxyl groups on the surface of Fe3O4 nanoparticles modified with DMSA can be used for the coupling of biomolecules, constructing nanoprobes for biological detection and analysis

^{Related Information}

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