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Description
Invivo Anti-Mouse NKG2D Recombinant mAbProduct Specification Host Armenian hamster Antigen NKG2D Synonyms NKG2 D type II integral membrane protein; Killer cell lectin like receptor subfamily K member 1; NK cell receptor D; NKG2 D activating NK receptor; CD314; Nkg2d; Klrk1 Location Cell membrane Accession O54709 Clone Number S 3681 Antibody Type Recombinant mAb Application ELISA, WB, in vivo NKG2D blockade Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95%(Determined by
Product Specification
| Host | Armenian hamster |
| Antigen | NKG2D |
| Synonyms | NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD314; Nkg2d; Klrk1 |
| Location | Cell membrane |
| Accession | O54709 |
| Clone Number | S-3681 |
| Antibody Type | Recombinant mAb |
| Application | ELISA, WB, in vivo NKG2D blockade |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH 7.4, Contains no stabilizers or preservatives |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
NKG2D is a type II transmembrane C-type lectin-like receptor expressed as a disulfide-linked homodimer on virtually all human and mouse NK cells, γδ T cells, and CD8+ αβ T cells; upon engagement by stress-inducible MHC class I–related ligands (MICA/B, ULBPs in humans; Rae-1, H60, Mult1 in mice) it couples to the DAP10 (and in mouse also DAP12) adaptor to deliver phosphotyrosine signals that powerfully lower activation thresholds, costimulate cytotoxicity, and drive proliferation and cytokine release, thereby forming a central surveillance axis that eliminates transformed, infected, or otherwise stressed cells but also contributes to immune-mediated pathologies when ligand expression becomes chronic.
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