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Description
DR5 Recombinant Rabbit mAb (S-649-36)Product Specification Host Rabbit Antigen DR5 Synonyms Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF related apoptosis inducing ligand receptor 2 (TRAIL receptor 2; TRAIL R2), CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9 Immunogen Synthetic Peptide Location Membrane Accession O14763 Clone Number S 649 36 Antibody Type Recombinant mAb Application WB, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | DR5 |
| Synonyms | Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL receptor 2; TRAIL-R2), CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | O14763 |
| Clone Number | S-649-36 |
| Antibody Type | Recombinant mAb |
| Application | WB, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 |
Background
DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
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