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Description
Alexa Fluor® 488 Mouse Anti-Human CD11a/CD18 Antibody (S-2969)Product Specification Host Mouse Antigen CD11a CD18 Synonyms Integrin alpha L; CD11 antigen like family member A; Leukocyte adhesion glycoprotein LFA 1 alpha chain (LFA 1A); Leukocyte function associated molecule 1 alpha chain; ITGAL; CD11A; Integrin beta 2; Cell surface adhesion glycoproteins LFA 1 CR3 p150,95 subunit beta; Complement receptor C3 subunit beta; ITGB2; MFI7 Location Cell membrane Accession P05107P20701 Clone Number S 2969 Antibody Type
Product Specification
| Host | Mouse |
| Antigen | CD11a/CD18 |
| Synonyms | Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A); Leukocyte function-associated molecule 1 alpha chain; ITGAL; CD11A; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; ITGB2; MFI7 |
| Location | Cell membrane |
| Accession | P05107、P20701 |
| Clone Number | S-2969 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD18, also known as integrin β2, is a 95 kDa glycoprotein that is a crucial component of several β2 integrins. These integrins are heterodimeric type I transmembrane proteins composed of a variable alpha chain (CD11a-d) and the common beta chain CD18. The CD18 protein is encoded by the ITGB2 gene in humans. It plays a significant role in cellular adhesion and immune responses. When CD18 binds with different alpha chains, it forms various heterodimers such as lymphocyte function-associated antigen-1 (LFA-1) with CD11a, and Macrophage-1 antigen receptor (Mac-1) with CD11b. These heterodimers are involved in processes like leukocyte adhesion to endothelial cells, phagocytosis, and immune cell activation. Deficiencies in CD18 expression can lead to adhesion defects in white blood cells, impairing the immune system's ability to fight infections.
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