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Description
GMF-β Protein, HumanProduct Specification Species Human Synonyms Glia Maturation Factor beta,GMFB Accession P60983 Amino Acid Sequence Ser2 His142 Expression System E. coli Molecular Weight Approximately 16. 6 kDa, a single non glycosylated polypeptide chain containing 141 amino acids. Purity 96% by SDS PAGE or HPLC. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 20 mM PB, with 150 mM NaCl, pH 7. 4. Reconstitution Before use
Product Specification
| Species | Human |
| Synonyms | Glia Maturation Factor beta,GMFB |
| Accession | P60983 |
| Amino Acid Sequence | Ser2-His142 |
| Expression System | E.coli |
| Molecular Weight | Approximately 16.6 kDa, a single non-glycosylated polypeptide chain containing 141 amino acids. |
| Purity | ＞96% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20 mM PB, with 150 mM NaCl, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
The glia maturation factor beta belongs to the actin-binding proteins ADF family, GMF subfamily. It contains an ADF-H domain, but the research of crystallography and NMR reveals that there are structures different between human and mouse ADF-H domain. GMF-β appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the progression of certain auto immune diseases, possibly through its ability to induce the production and secretion of various pro inflammatory cytokines. It also inhibition of proliferation of tumor cells and it has also been shown to function intracellularly as a modulator of MAP kinase signal transduction. Recombinant human GMFβis a 16.6kDa protein containing 141 amino-acid residues.
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