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Description
E2F4 Recombinant Rabbit mAb (S-586-214)Product Specification Host Rabbit Synonyms Transcription factor E2F4, E2F 4 Immunogen Synthetic Peptide Location Nucleus Accession Q16254 Clone Number S 586 214 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Synonyms | Transcription factor E2F4, E2F-4 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q16254 |
| Clone Number | S-586-214 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:100 | |
| ICC | 1:100-1:500 | |
| ICFCM | 1:50 |
Background
E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
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