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Description
Alexa Fluor 647-Labeled ICAM-1/CD54 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms BB2,CD54 antigen,CD54,cell surface glycoprotein P3. 58,human rhinovirus receptor,ICAM1,ICAM 1,intercellular adhesion molecule 1 (CD54) Accession P05362 1 Amino Acid Sequence Gln28 Glu480 with hIgG1 Fc Tag at C Terminus Expression System HEK293 Molecular Weight 49 72kDa (Reducing) Conjugation Alexa Fluor 647 Tag Human IgG1 Fc Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months
Product Specification
| Species | Human |
| Synonyms | BB2,CD54 antigen,CD54,cell surface glycoprotein P3.58,human rhinovirus receptor,ICAM1,ICAM-1,intercellular adhesion molecule 1 (CD54) |
| Accession | P05362-1 |
| Amino Acid Sequence | Gln28-Glu480 with hIgG1 Fc Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 49-72kDa (Reducing) |
| Conjugation | Alexa Fluor® 647 |
| Tag | Human IgG1 Fc |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt stored at -20 to -80℃. |
| Reference | 1、Gu H F. et al. (2013) Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy. Front Endocrinol. 3: 179. |
Background
ICAM-1 is a cell surface glycoprotein expressed at a low basal level in immune, endothelial (EC) and epithelial cells, but is up-regulated in response to inflammatory stimulation. The function of ICAM-1 has been best studied in leukocyte transendothelial migration (TEM), where ICAM-1 regulates leukocyte rolling and adhesive interactions with the vessel wall, and guides leukocyte crossing of the endothelial layer. More recently, functional studies identified several new roles of ICAM-1 in epithelial injury-resolution responses, innate and adaptive immune responses in inflammation, and tumorigenesis.
Guidelines
Following recommended dosage for experiments strictly. If the population clustering is not distinct, the recommended dosage could be appropriately increased by 2–5 folds.
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