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Description
CD3 gamma His Tag Protein, HumanProduct Specification Species Human Synonyms CD3 gamma, CD3G Accession P09693 Amino Acid Sequence Gln 23 Ser 116 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 15 25kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | CD3 gamma, CD3G |
| Accession | P09693 |
| Amino Acid Sequence | Gln 23 - Ser 116 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 15-25kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1. The role of the different CD3γ domains in TCR expression and signaling. Frontiers in Immunology, 13, 978658. |
Background
CD3γ (Cluster of Differentiation 3 gamma) is a critical subunit of the T cell receptor (TCR) complex. It is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. The CD3γ chain, together with CD3δ, CD3ε, and the CD3ζ homodimer, forms the invariant CD3 signaling module that associates with the variable TCRαβ or TCRγδ chains.
The primary function of CD3γ is to mediate signal transduction upon antigen recognition. Like other CD3 subunits, CD3γ contains three immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic domain. Upon TCR engagement with peptide-MHC complexes, these ITAMs are phosphorylated by Src-family kinases (LCK and FYN), initiating downstream signaling cascades that lead to T cell activation, proliferation, and differentiation.
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