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Description
ROR2 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms ROR2, NTRKR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, BDB1 Accession A1L4F5 Amino Acid Sequence Glu34 Gly403, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | ROR2, NTRKR2, Receptor Tyrosine Kinase Like Orphan Receptor 2, BDB1 |
| Accession | A1L4F5 |
| Amino Acid Sequence | Glu34-Gly403, with C-terminal Human IgG1 Fc EVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 52-61kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Liu Y. et al. (2007) Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. Mol Endocrinol. 21: 3050-3061. 2、Afzal A R. et al. (2000) Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet. 25: 419-422. 3、van Bokhoven H. et al. (2000) Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat Genet. 25: 423-426. |
Background
Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is broadly expressed during embryonic development and can be found in cells of all three germ layers as well as in most organ tissues. ROR2 binds the Wnt family ligand, Wnt-5a, to activate non-canonical Wnt signaling pathways. Activation of ROR2 signaling promotes cellular proliferation, differentiation, cell-polarization, and migration. ROR2 is important for osteogenic and chondrogenic differentiation of mesenchymal stem cells. ROR2 is also involved in neurite outgrowth and synapse development in the brain.
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4.6 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 5
This one is a favorite!
Format: Board book
This really holds the interest of a toddler who loves animals, animal sounds, and pushing buttons! Good sound quality, and it's nice to have something to read about the animals instead of just labeled pictures.
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Reviewed in the United States on November 23, 2024
★★★★★ 5
All grandkids enjoyed these
Format: Board book
The grandkids always enjoy Eric Carle sound books. The older one reads the stories and the younger one likes to just push the buttons and listen and then say what the animal is. The sound is always nice and clear and the photos on the buttons are easily recognizable. As an added bonus these were offered at a great holiday price.
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Reviewed in the United States on January 5, 2025
★★★★★ 4
Battery issue
Format: Board book
Battery came dead
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Reviewed in the United States on March 15, 2026
★★★★★ 5
Initially Scary, Now Beloved Animal Sounds Book
Format: Board book
Got this for my 1.5 y.o. for the holidays. She was initially scared of the sounds (which are pretty loud and not volume adjustable). We read it several times without hitting the buttons. Then I would occasionally push some of the buttons for her. Later she got bolder and started playing with it by herself, pushing them at random and perusing the book. Now she has the positions of every button memorized and loves this book. We call it the Big Book and it was in the daily rotation for weeks. We still pull it out from time to time, and she is able to play with it independently as well as have us read the stories to her. Totally worth the money and shelf space. 10/10 would buy again.
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Reviewed in the United States on March 13, 2022
★★★★★ 5
Grandkids love the book and especially the flashlight.
Format: Board book
All of Eric Carle's books are great. My 2 1/2 yr old granddaughter is especially interested in flashlights these days, but household flashlights are too bright for kids who tend to flash them in people's faces. This is a low-beam flashlight that compliments a fun book and she loves them both.
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Reviewed in the United States on December 28, 2020