SKU: 13306086084

GluN3B Recombinant Rabbit mAb (S-2320-3)

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Description

GluN3B Recombinant Rabbit mAb (S-2320-3)Product Specification Host Rabbit Antigen GluN3B Synonyms Glutamate receptor ionotropic, NMDA 3B; GRIN3B Immunogen Recombinant Protein Location Cell membrane Accession O60391 Clone Number S 2320 3 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Positive Sample CHO transfected with GluN3B Myc His fusion protein Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage

Product Specification


Host Rabbit
Antigen GluN3B
Synonyms Glutamate receptor ionotropic, NMDA 3B; GRIN3B
Immunogen Recombinant Protein
Location Cell membrane
Accession O60391
Clone Number S-2320-3
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC
Reactivity Hu, Ms
Positive Sample CHO transfected with GluN3B-Myc-His fusion protein
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:500-1:1000 Ms
ICC 1:500 Ms

Background

GluN3B, encoded by the GRIN3B gene, is a unique and atypical subunit of the N-methyl-D-aspartate receptor (NMDAR) that fundamentally alters the receptor's functional properties when co-assembled with obligatory GluN1 subunits and conventional GluN2 subunits. Unlike other NMDAR subunits, GluN3B contains a distinct ligand-binding domain that renders the resulting heterotrimeric or heterotetrameric receptors insensitive to the co-agonist glycine and significantly reduces their calcium permeability and single-channel conductance, effectively acting as a dominant-negative modulator that dampens excitatory synaptic transmission. Primarily expressed in specific brain regions such as the thalamus, striatum, and during early postnatal development in the cortex, GluN3B plays a critical role in refining neural circuits by limiting excessive NMDAR activity, thereby influencing processes like synaptic plasticity, motor coordination, and sensory gating; furthermore, dysregulation or mutations in GRIN3B have been implicated in various neurological disorders, including schizophrenia, Huntington's disease, and rare forms of epilepsy, highlighting its importance as a potential therapeutic target for modulating glutamatergic signaling without completely abolishing NMDAR function.

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SKU: 13306086084

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interesting and fresh perspective on the American civil war
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Fresh perspective on the well known American Civil War. I appreciate Dr Taylor’s emphasis on the preservation of slavery over the states’ rights argument for why the American Civil War was fought.
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Reviewed in the United States on April 30, 2026
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This is the best oil that I ever used.I have used it in my Toyota Noah 2006-2007 model…The engine is as quiet as new…wanted to see how it would perform.It has clocked 3,500km.This is good and have recommended to my friends and family
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Reviewed in the United States on May 23, 2026
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Dawn S.
Battle Creek, US
★★★★★ 5
Top-tier engine protection that runs quiet and smooth
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I’ve used Castrol EDGE in a couple of our vehicles and always come back to it for consistent performance. It extends the time between oil changes and holds up well under both daily driving and highway mileage. We don't "extend the time" though. It's changed, on the dot, every time. The consistency and quality of the oil's condition at change, though, is easily able to be seen that it would go for much longer. Engine runs quieter, and I’ve noticed better fuel efficiency over time compared to conventional oil. Whether that's how attentively I drive and watch the mileage meter on the dash or the oil - is up for debate ;) It doesn’t burn off as quickly either, which is great if you’re keeping an eye on long-term engine health. The bottle design pours cleanly with a smart spout, which saves unnecessary messes in the garage. Pros: Strong wear protection and long-lasting Improves engine quietness Easy-pour design Tip: Use it with a high-quality oil filter for maximum benefit don’t skimp on either part and you'll be golden.
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