SKU: 13762879093

Ephrin-B1 Fc Chimera Protein, Human

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Description

Ephrin-B1 Fc Chimera Protein, HumanProduct Specification Species Human Accession P98172 Amino Acid Sequence Leu28 Gly232, with C terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 58 70kDa (Reducing) Purity 95% by SDS PAGE&RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.

Product Specification


Species Human
Accession P98172
Amino Acid Sequence

Leu28-Gly232, with C-terminal Human IgG1 Fc

Expression System HEK293
Molecular Weight

58-70kDa (Reducing)

Purity

>95% by SDS-PAGE&RP-HPLC

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Background

There are two subfamilies of Ephrins, Ephrins-As (Ephrin-A1 to A10), and Ephrins-Bs (Ephrin-B1 to B6), binding to the tyrosine receptor kinases EphAs and EphBs, respectively. Ephrins-As have a GPI-anchor at their C-terminus. Ephrin-B ligands are transmembrane proteins. The extracellular region of Eph receptors (there are 10 EphAs and 6 EphBs in vertebrates) consists of an N-terminal Ephrin-binding domain, a cysteine-rich region (EGF-like motif) and two fibronectin type-III motifs. A juxtamembrane segment, a tyrosine kinase domain, a sterile-α-motif (SAM), and a PDZ binding motif are part of the intracellular region of the Eph receptors and are involved in bidirectional (forward and reverse) signaling through the small GTPases Rac, cdc42, and Rho. Ephrins/Ephs have many different physiological roles, such as cell adhesion, cell migration, and axon guidance. During development of the CNS, Ephrins mainly act as axon repellants in different areas, including the optic tectum, the anterior commissure, and the corticospinal tract (CST). Ephrins/Ephs play an important role in the regulation of synapse formation, function, and plasticity. Furthermore, Ephrins/Ephs are important in adults for the maintenance of synapses, cell proliferation, neurogenesis, and apoptosis in the rostral migratory stream and subventricular zone. In vitro, Ephrins exhibit activities in growth cone collapse and axon growth inhibition for many different neuronal types. After CNS injury in vivo, many Ephrins/Ephs are upregulated. For example, after spinal cord injury, EphA3, A4, A6, and A8, EphB3, EphB2, and Ephrin-B2 expression levels are increased, raising the possibility that they may contribute to the lack of axon regeneration. The ephrin-B-EphB family plays a critical role in the maintenance of bone homeostasis. Ephrin-Eph signaling is bidirectional; thus, the binding between ligand and receptor triggers a signal transduction cascade downstream of both molecules. The bidirectional nature of ephrin-Eph signaling is the basis of its role in coupling bone resorption to bone formation. Osteoblasts express both ephrin-A and B ligands and EphA and EphB receptors, whereas osteoclasts express only ephrins A2, B1, and B2, with no detectable EphB or EphA1, EphA2, and EphA4 receptors. Osteocytes also express EphB4 and ephrins B1 and B2.

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SKU: 13762879093

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4.5 ★★★★★
Based on 25 reviews
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Verified Purchase
D. Rae
New York, US
★★★★★ 5
Perfect consistency and gentle enough for rosacea
Scent: Honey & Sweet Orange, Size: 5 Ounce (Pack of 1)
This is one of the best tallow-based moisturizers I’ve tried. I rarely leave reviews, but this product truly deserves one. The consistency is perfect—rich and nourishing without feeling heavy or greasy, and it absorbs beautifully into the skin. It doesn’t feel thick or like you’re wearing a mask. The scent is also very mild with a light hint of orange that fades quickly after application, which I really appreciate since many natural products can be overpowering. I have rosacea and very sensitive skin, and this is one of the few natural skincare products that hasn’t caused irritation or redness. It leaves my skin feeling calm, hydrated, and balanced. If you’re looking for a high-quality tallow moisturizer for sensitive or rosacea-prone skin, I highly recommend giving this one a try.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 7, 2026
R
Verified Purchase
RKL
Houston, US
★★★★★ 3
Too thick and greasy for my sensitive skin
Scent: Honey & Sweet Orange, Size: 5 Ounce (Pack of 1), Scent: Honey & Sweet Orange, Size: 5 Ounce (Pack of 1)
This is the fifth different beef tallow product that I’ve tried in the last few months. I’ve been in search for the perfect one that doesn’t leave my skin feeling greasy. I was really excited to try this after reading the great reviews, however this product is not for me. It is very thick, almost waxy like and I almost have to use my fingernail just to get it out. I know it’s not whipped and that it’s a balm, but it is way too thick and heavy for me. I’ve been looking for a nice moisturizer for my face, but this is far too greasy for my oily sensitive skin, especially on my face. I have been using it on my chest and neck and even on my legs and it is very hydrating and makes my chest extremely soft, even 12 hours after I put it on. I love that it’s a clean product with great ingredients. It has a very mild scent, almost non-detectable. I was really hoping this would be a good one for my face, sadly it did not hit the mark for my sensitive skin.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 3, 2026
R
Verified Purchase
Renee
Carnegie, US
★★★★★ 5
Amazing!
Scent: Unscented, Size: 8 Ounce (Pack of 1), Scent: Unscented, Size: 8 Ounce (Pack of 1)
I’ve been using this for a few days now and my skin has already improved so much!! My skin feels sooo much smoother, especially in the areas where my dry spots were really showing. This tallow helped smooth everything out and absorbed into my skin amazingly. I honestly have nothing but good things to say about this product. I also love that it comes in a big jar because I use moisturizer 24/7, so this will definitely last me a while. It’s been especially amazing for my eczema it cleared up within just a few days! I will forever repurchase this and recommend it to everyone. There’s no fragrance, which I love. It does feel a little greasy at first, but that goes away pretty quickly once it absorbs. The application, size, and absorption are all amazing 💕
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 26, 2026
L
Verified Purchase
Luz Lopez
West Palm Beach, US
★★★★★ 5
very amazing product
Scent: Unscented, Size: 8 Ounce (Pack of 1), Scent: Unscented, Size: 8 Ounce (Pack of 1)
i love this product. it’s very smooth and buttery. no scent and truly good for skin.
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Reviewed in the United States on May 25, 2026
M
Verified Purchase
MC
Whiting, US
★★★★★ 4
Not bad for the price point.
Scent: Unscented, Size: 8 Ounce (Pack of 1)
I don't mind this product; it's well-priced; however, in practice, it was slightly too oily. I prefer other beef tallow products, or even just straight-up beef tallow, rather than this product. Because I have severe eczema on my hands, I prefer tallow blends that have faster absorption. However, this product is perfectly suited for use as a night moisturizer or as a hand mask. I would probably buy this again if the formulation were less oily/greasy next time.
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Reviewed in the United States on May 30, 2026

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