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Description
CTSK Recombinant Rabbit mAb (S-1370-278)Product Specification Host Rabbit Antigen CTSK Synonyms Cathepsin K; Cathepsin O; Cathepsin O2; Cathepsin X; CTSO; CTSO2 Immunogen Synthetic Peptide Location Secreted, Lysosome, Apical cell membrane Accession P43235 Clone Number S 1370 278 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample U 87 MG, SK MEL 28, Jurkat, RAW264. 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | CTSK |
| Synonyms | Cathepsin K; Cathepsin O; Cathepsin O2; Cathepsin X; CTSO; CTSO2 |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Lysosome, Apical cell membrane |
| Accession | P43235 |
| Clone Number | S-1370-278 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | U-87 MG, SK-MEL-28, Jurkat, RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
Cathepsin K (CTSK) is a lysosomal cysteine protease predominantly expressed in osteoclasts and belongs to the peptidase C1 protein family. It plays a crucial role in bone remodeling and resorption by degrading collagen and other matrix proteins. CTSK is the most active mammalian collagenase and can cleave both the helical and telopeptide regions of type I collagen, which is abundant in bone. Besides its role in bone metabolism, CTSK is also found in various cancers, such as breast cancer and melanoma, where it contributes to tumor invasiveness and metastasis. Mutations in the CTSK gene can lead to pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
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