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Description
Cadherin 17 Recombinant Rabbit mAb (SDT-R151)Product Specification Host Rabbit Antigen Cadherin 17 Synonyms Intestinal peptide associated transporter HPT 1, Liver intestine cadherin, LI cadherin Immunogen N A Location Cell membrane Accession Q12864 Clone Number SDT R151 Antibody Type Recombinant mAb Application IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Rabbit |
| Antigen | Cadherin 17 |
| Synonyms | Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, LI-cadherin |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | Q12864 |
| Clone Number | SDT-R151 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | null |
| IF | 1:1000 | null |
Background
Cadherin 17 is a member of a multigene family of calcium-dependent, transmembrane proteins that mediates cell-cell adhesion, plays important roles during embryogenesis, and is crucial for tissue morphogenesis and maintenance. Cadherin 17 is exclusively expressed in the epithelial cells of embryonic and adult small intestine and colon, and pancreatic ducts. It has also been reported to be frequently expressed in adenocarcinomas arising in the gastrointestinal tract and pancreas. Owing to its restricted expression in these groups of tumors, cadherin 17 has proven to be a useful immunohistochemical marker for assisting in distinguishing these neoplasms from other malignancies with which they may be confused [PMID: 24508695].
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