SKU: 14866102891

HVEM/TNFRSF14 His Tag Protein, Human

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Description

HVEM/TNFRSF14 His Tag Protein, HumanProduct Specification Species Human Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270 Accession Q92956 1 Amino Acid Sequence Leu39 Val202, with C terminal His Expression System HEK293 Molecular Weight 30 43kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270
Accession Q92956-1
Amino Acid Sequence Leu39-Val202, with C-terminal His
Expression System HEK293
Molecular Weight

30-43kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76. 

2.Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.

Background

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily.It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

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SKU: 14866102891

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4.2 ★★★★★
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Twark Main
Chelsea, US
★★★★★ 5
foundational, dense
Format: Paperback
An extremely important book for anyone interested in the humanities or the sciences, particularly astronomy. It's a foundational work to help guide us towards understanding all of the past, present, and possibly future of humanity. The authors' style is a bit dense and may be more greatly appreciated by polyglots, but they get their points across extremely thoroughly.
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Reviewed in the United States on January 18, 2026
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Jaybird
Draper, US
★★★★★ 5
Deepest Wisdom Within
Format: Paperback
Fantastic and engaging read. A must for serious comparison into myths. Esoteric wisdom found along paths of clear knowledge from the collective nature source of all epochal imagery (hidden history of the Ancients) unfolds within. Helpful in putting much confusion of modernity into context. Causes one to consider the scientific accomplishments of previous cultures rather than pondering thru occulted and poorly choreographed explanations about how such advanced civilizations achieved their grandeur; which were obviously far more advanced technologically than NASA is by light years! We are re-discovering what many peoples already understood long long ago. Recorded and referenced histories go back 100s of thsds of years and more. The book does not make judgements upon written records or of oral traditions but would implore readers come to a self realization by discovering information that causes one to expand their own minds and concur with known facts and of what remains from the past. High above the casual status quo official, sidetracked narratives that lead to reckless abandon and despair. Dialed in and deep! A real treasure trove. Highly recommended.
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Reviewed in the United States on April 15, 2019
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Tom Waylett
Omaha, US
★★★★★ 5
Packed with knowledge and mystery!
Format: Paperback
I gave this book 5 stars because this is an exhaustive compendium of mythological knowledge in one short (505 pages) volume. It is professorial in writing design, which includes excerpts in Latin, French and German, as well as the many words and phrases from India, Mesopotamia, northern Europe, Pacifiic islands and so forth. I recommend reading the appendices in the order they are referred to in the main text. I read them last and did not glean an understanding that accompanied the chapters. All in all, this is a researcher's book with 29 pages of bibliography material, with extensive notes at the bottom of the pages so one can stay on text. Good luck and enjoy the perusal of mythology, astronomy/astrology, history, poetry and fable. Great reading!
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Reviewed in the United States on September 8, 2015
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Serendipitygirl
Grantham, US
★★★★★ 4
Interesting connections made.
Format: Paperback
I bought this because or had been referred to in several other excellent books I've read. Very scholarly and good case made but a bit dry and overdone/redundant at times when making a point. And if you've studied a lot, nothing really new revealed- but if just starting down this road, some great comparisons made.
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Reviewed in the United States on August 19, 2025
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David Warner Mathisen
Battle Creek, US
★★★★★ 5
Seminal
Format: Paperback
As many have noted, Hamlet's Mill is not an "easy" read, but it is an absolutely worthwhile experience not only to read but to re-read this seminal thesis on the transmission of ancient astronomical knowledge through mythology and legend. Perhaps the fact that a reader must wrestle with this text is part of the reason that it has generated so many fruitful inquiries and theories by later authors. The entire book is rich with ideas, many of which the authors drop and then pick up again and again later in the text, some of which are simply left for later analysts to pursue further on their own. Slice into it at any point and you will find a rich vein of material that can suggest new avenues for you to explore in the ancient history and literatures of the world. Sometimes an easy read or a text that hands you all of its answers and does the work for you is not "what the doctor ordered." Hamlet's Mill definitely makes more sense the second and even third time through. That in and of itself makes this book worth your while -- it's a gift that keeps on giving, a book you can keep on reading, even after you reach the end!
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Reviewed in the United States on April 21, 2011

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