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Description
EGFR (L858R) Recombinant Rabbit mAb, PBS Only (SDT-421-202)Product Specification Host Rabbit Antigen EGFR (L858R) Synonyms Epidermal growth factor receptor; Proto oncogene c ErbB 1; Receptor tyrosine protein kinase erbB 1; ERBB; ERBB1; HER1 Immunogen Synthetic Peptide Location Cell membrane, Endoplasmic reticulum membrane Accession P00533 Clone Number SDT 421 202 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IP Reactivity Hu Positive Sample H1975 Purification Protein A Concentration 1 mg ml
Product Specification
| Host | Rabbit |
| Antigen | EGFR (L858R) |
| Synonyms | Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Endoplasmic reticulum membrane |
| Accession | P00533 |
| Clone Number | SDT-421-202 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Positive Sample | H1975 |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
| IP | 1:50 | Hu |
| IHC-P | 1:100-1:200 | Hu |
Background
EGFR is a 170 kDa transmembrane receptor that induces tyrosine kinase activity affecting cell growth. EGFR mutations can occur in various parts of the gene. In NSCLC, the mutations occur almost exclusively in the exons encoding the kinase domain (exons 18 to 21). They most commonly include the in-frame deletion of exon 19 (del19) and L858R mutation in exon 21.Del19 constitutes 44–51%, and exon 21 L858R mutation constitutes 38–40%.
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Exchange/Return Notes
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