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Description
Alexa Fluor® 488 Mouse Anti-Human CD279 (PD-1) Antibody (S-R570)Product Specification Host Mouse Antigen CD279 (PD 1) Synonyms Programmed cell death protein 1; Protein PD 1; hPD 1; PD1; PDCD1 Location Cell membrane Accession Q15116 Clone Number S R570 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | CD279 (PD-1) |
| Synonyms | Programmed cell death protein 1; Protein PD-1; hPD-1; PD1; PDCD1 |
| Location | Cell membrane |
| Accession | Q15116 |
| Clone Number | S-R570 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
Programmed cell death protein 1 (PD-1), also known as CD279, is a type I transmembrane protein belonging to the CD28 immunoglobulin superfamily. It is encoded by the Pdcd1 gene and consists of 288 amino acids, including an extracellular IgV-like domain, a transmembrane region, and a cytoplasmic tail. PD-1 is expressed on activated T cells, B cells, macrophages, dendritic cells, and natural killer cells. Its cytoplasmic domain contains two tyrosine residues that form an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM), which play key roles in inhibiting T cell receptor signaling. PD-1 interacts with its ligands PD-L1 and PD-L2 to negatively regulate immune responses, contributing to peripheral tolerance and preventing autoimmune diseases. However, this inhibitory function can also suppress anti-tumor immunity, making PD-1 a promising target for cancer immunotherapy.
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4.7 ★★★★★
Based on 28 reviews
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Product Reviews
★★★★★ 5
Sleek and stylish
Color: Dark Tort/Green, Polarization Type: Non-Polarized, Lens Width: 50 Millimeters, Color: Dark Tort/Green, Polarization Type: Non-Polarized, Lens Width: 50 Millimeters
Sleek and stylish sunglasses in a dark tortoise pattern. Simple classic design. Unisex design and fit. I especially like the wired sides that are easy and safe to customized to your head, ear, nose fit and comfort. Seems like a good value for quality, design, comfort and fit. Comes with a slim case. Nice sunglasses overall!
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Reviewed in the United States on October 9, 2025
★★★★★ 5
Sturdy & well made & they stay in place!
Color: Dark Tort/Green, Polarization Type: Non-Polarized, Lens Width: 50 Millimeters, Color: Dark Tort/Green, Polarization Type: Non-Polarized, Lens Width: 50 Millimeters
Wow, these are really nice & well made sunglasses!! I love them better than my prescription sunglasses that I paid a ton for that I really don't need when I am out in the sun. They have some weight to them and don't feel like cheap sunglasses you get off the rack in a drugstore and they fit comfortably on my face and nose. The build-in nose pads hold them in place so they don't slip down my nose!! They come packaged with care in a nice carrying case and there's a lens-cloth included in the package. The price on these won't break the bank and I'm really glad to have found them as I do spend a lot of time in the sun or bright light.
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Reviewed in the United States on August 25, 2025
★★★★★ 2
Soft case, not universal, not worth the price
Color: Dark Tort/Green, Polarization Type: Non-Polarized, Lens Width: 50 Millimeters, Color: Dark Tort/Green, Polarization Type: Non-Polarized, Lens Width: 50 Millimeters
I didn't pay for these, but priced at more than $70, I wanted to try them. The description is confusing if not misleading, stating "Quay merges music and fashion to create trend-forward designer eyewear for any moment or mood." Given the exorbitant price for a brand I never heard of (e.g., Raybans may be overpriced, but they come with a 24 month warranty and it's a brand that's been around a long time), I thought that these shades played music. How else are ordinary $10 sunglasses priced at nearly $100? How do they "merge music"??? Answer: they don't. They're sunglasses.
They're also not "Designed for a universal fit," because they're way too big for me, and I have a normal-sized head, and I have bought many pairs of sunglasses and nearly all of them fit just fine. In fact, this is only the second time I ever tried on a pair and they were too large, but the other time, those sunglasses, which were a lot more stylish than these, cost around $20.
The case is soft, which is ok, I guess. Some people prefer it but to me, if a case will not provide any protection from being crushed, e.g., sat upon, or had something heavy put on top, then it's not a very good case. They also included a nice lens cloth.
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Reviewed in the United States on August 21, 2025
★★★★★ 5
Impressive lenses quality for polarizing that works
Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters, Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters
As much quality of polarized glasses that you can get for the value here with actively polarizing glasses that not only block bright sunlight but dramatically reduces glare and bright rays on light surfaces even compared to some "better" sunglasses that aren't polarized. You really have to test them yourself to see, and if you like the lenses, you'll like this! The lenses are dark grey, so they keep the true color of grass, trees, sky, everything, just with dimming effects which I prefer, it's not a massive change changing colors, it's more natural to me.
The quality & style is high with the whole glasses feeling sturdy and smooth as you open them and put them on. It's made with some basic plastic frames, they have a nice softer texture that's almost silicone feeling, so they feel great & soft but also it helps support sitting on the nose and ears. Perfect fit (I'm a man, average head I would say lol) I haven't noticed any sliding around at all with these!
Lenses are made from PC with polarizing. They feel thick, sturdy, and stay clean. I have only noticed one fingerprint so far after wearing them for 2 weeks. It definitely is a weekender look and case build. The edges sit a little further away from the skin so depending on the angle there can be a little glare and reflections of your eyes cheeks in the lenses. If I had to choose a part I don't like the most that would be it. Pretty glarey on the inside. On the outside, it's reflective to any light so lots of sunlight will reflect off and hide your eyes which I like.
Aesthetics, usability, quality for the value, all make this stand out to me and I would definitely be packing this when I'll be in a lot of light, even for driving with the anti-reflection polarized lenses. Very impressed with this pair. I would like the sides to be closer but I guess I would have to get a different style, these are weekender, so all in all I'm a big fan!
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Reviewed in the United States on September 14, 2025
★★★★★ 5
Neat design with high quality lenses
Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters, Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters
These Quay sunglasses combine a unique bridge design with a sleek, modern style that stands out. At first, I wasn’t sure if I’d like the way they sat on my nose, but after wearing them, I found the look and fit to be both flattering and comfortable.
The frames are lightweight yet sturdy enough for daily use, and the fit is secure without slipping during regular activity. The polarized lenses are excellent optical quality, reducing glare effectively while staying distortion-free, which makes them great for driving and outdoor wear. I’ve worn them for several hours at a time with no discomfort.
For the price, these sunglasses strike a nice balance between fashion and function, offering a high-quality lens and a stylish frame at a reasonable value.
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Reviewed in the United States on October 1, 2025