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Description
GM-CSF Protein, RatProduct Specification Species Rat Synonyms Granulocyte macrophage colony stimulating factor, Colony stimulating factor (CSF), GM CSF Accession P48750 Amino Acid Sequence Ala18 Lys144 Expression System E. coli Molecular Weight 14. 5 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris,100mM NaCl, pH8. 0 Reconstitution Reconstitute at 0. 1
Product Specification
| Species | Rat |
| Synonyms | Granulocyte-macrophage colony-stimulating factor, Colony-stimulating factor (CSF), GM-CSF |
| Accession | P48750 |
| Amino Acid Sequence | Ala18-Lys144 |
| Expression System | E.coli |
| Molecular Weight | 14.5 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris,100mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Cell Mol Immunol. 2021 Aug;18(8):2057-2058. Epub 2021 Jul 19. |
Background
Granulocyte-macrophage colony-stimulating factor (GM-CSF), which belongs to the colony-stimulating factor (CSF) superfamily and was originally identified as a hemopoietic growth factor, is mainly produced by lymphocytes and innate lymphoid cells. During inflammation, GM-CSF is principally produced by T helper (Th) cells and acts as a communication conduit between myeloid cells and tissue-invading lymphocytes. GM-CSF increased Treg numbers and its immunoregulatory activities that led directly to dopaminergic neuronal protection in the substantia nigra and striatum
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