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Description
Human folate receptor alpha Recombinant Rabbit mAb (SDT-719-20-2)Product Specification Host Rabbit Antigen Human folate receptor alpha Synonyms FR alpha, Adult folate binding protein (FBP), Folate receptor 1, KB cells FBP, Ovarian tumor associated antigen MOv18, FOLR1, FOLR Immunogen Synthetic Peptide Location Cell membrane Accession P15328 Clone Number SDT 719 20 2 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Human folate receptor alpha |
| Synonyms | FR-alpha, Adult folate-binding protein (FBP), Folate receptor 1, KB cells FBP, Ovarian tumor-associated antigen MOv18, FOLR1, FOLR |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P15328 |
| Clone Number | SDT-719-20-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:250 | null |
Background
Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. FRα, due to its high expression in some tumors, is an attractive therapeutic target for the development of novel anti-cancer agents in order to limit toxic side-effects on off-target tissues. FRa can be overexpressed by a number of epithelial-derived tumors including ovarian, breast, renal, lung, colorectal, and brain. Therefore, antibodies to FRa are being developed for use in targeted therapies, with one example being farletuzumab, in a phase III trial for ovarian cancer.
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