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Description
NKX3.1 Recombinant Rabbit mAb,PBS Only(S-2778-63)Product Specification Host Rabbit Antigen NKX3. 1 Synonyms Homeobox protein Nkx 3. 1; Homeobox protein NK 3 homolog A; NKX3A; NKX3 1 Immunogen Recombinant Protein Location Nucleus Accession Q99801 Clone Number S 2778 63 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample LNCaP, Jurkat, DU 145 Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | NKX3.1 |
| Synonyms | Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A; NKX3A; NKX3-1 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | Q99801 |
| Clone Number | S-2778-63 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | LNCaP, Jurkat, DU 145 |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
NKX3.1 is a prostate-specific homeodomain transcription factor that acts as a dose-dependent tumor suppressor by integrating developmental and metabolic cues: in the nucleus it partners with the androgen receptor, FoxA1 and serum response factor to coregulate differentiation genes and a “protein-trafficking” network that includes RAB3B, while in mitochondria it is imported via HSPA9 in response to oxidative stress, binds mtDNA and up-regulates electron-transport-chain genes to restore oxidative phosphorylation, thereby limiting ROS-induced DNA damage; haploinsufficiency, allelic loss or cancer-associated point mutations (e.g., T164A) disrupt these functions, leading to prostatic intraepithelial neoplasia, progression to castration-resistant disease, and reduced survival, whereas high mitochondrial NKX3.1 predicts favorable prognosis, and secreted NKX3.1 can even act as a para-transcription factor to inhibit growth of neighboring cells, illustrating its multifaceted role in prostate development, metabolic homeostasis and cancer suppression.
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