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Description
SLC25A22 Recombinant Rabbit mAb (S-2780-15)Product Specification Host Rabbit Antigen SLC25A22 Synonyms Mitochondrial glutamate carrier 1; GC 1; Glutamate H(+) symporter 1; Solute carrier family 25 member 22; GC1 Immunogen Recombinant Protein Location Mitochondrion Accession Q9H936 Clone Number S 2780 15 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample PANC 1, HT 29, Caco 2, A431, HepG2, NIH 3T3, mouse brain, PC 12, rat brain
Product Specification
| Host | Rabbit |
| Antigen | SLC25A22 |
| Synonyms | Mitochondrial glutamate carrier 1; GC-1; Glutamate/H(+) symporter 1; Solute carrier family 25 member 22; GC1 |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion |
| Accession | Q9H936 |
| Clone Number | S-2780-15 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | PANC-1, HT-29, Caco-2, A431, HepG2, NIH/3T3, mouse brain, PC-12, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:100 | Hu |
| ICC | 1:100 | Hu |
Background
SLC25A22 is a mitochondrial inner-membrane carrier that exchanges glutamate for H+ across the membrane, thereby providing the matrix with the key anaplerotic substrate needed to sustain the TCA cycle and amino-acid metabolism in neurons and β-cells; mutations in this gene abolish transport activity, cause autosomal-recessive early infantile epileptic encephalopathy-3 (EIEE3) with suppression-burst patterns, and are emerging as drivers of certain cancers by disrupting redox and metabolic homeostasis.
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