SKU: 18071008359

Histone H3 (citrulline R2 + R8 + R17) Recombinant Rabbit mAb (S-1733-17)

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Description

Histone H3 (citrulline R2 + R8 + R17) Recombinant Rabbit mAb (S-1733-17)Product Specification Host Rabbit Antigen Histone H3 (citrulline R2 + R8 + R17) Synonyms Histone H3. 1; Histone H3 a; Histone H3 b; Histone H3 c; Histone H3 d; Histone H3 f Immunogen Synthetic Peptide Location Nucleus Accession P68431 Clone Number S 1733 17 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%

Product Specification


Host Rabbit
Antigen Histone H3 (citrulline R2 + R8 + R17)
Synonyms Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f
Immunogen Synthetic Peptide
Location Nucleus
Accession P68431
Clone Number S-1733-17
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
Dot Blot 1:1000
WB 1:1000 Hu

Background

Histone H3 is a core component of the nucleosome, the fundamental unit of chromatin, which plays a crucial role in organizing genomic DNA within the eukaryotic nucleus. The citrullination of Histone H3 at arginine residues R2, R8, and R17 is a specific post-translational modification catalyzed by peptidyl arginine deiminase 4 (PAD4). This modification prevents methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and is associated with transcriptional repression. Citrullinated Histone H3 is also a key component of neutrophil extracellular traps (NETs) and acts as an autoantigen, contributing to the production of anti-citrullinated protein antibodies in various diseases, including sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma.

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SKU: 18071008359

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4.5 ★★★★★
Based on 22 reviews
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Product Reviews
A
Verified Purchase
Amazon Customer
Lake Worth, US
★★★★★ 5
Great for aggressive chewers - Great for clean teeth
I never thought these would stand up to my 60lb pittie puppy's chewing. But they are far and away her favorite toy and are holding up beautifully. One squeaker insert bit the dust -- which is not bad since it gives us one silent one. But otherwise they are holding up superbly to her powerful jaws. We have tried a lot of toys. So far, all the "for aggressive chewers" toys have been torn apart within days if we are lucky -- usually it's minutes. But these balls show little-to-no sign of wear. The squeakers are very loud which she loves can get a bit tiresome. So, as I mentioned, having one silent one is a great option. And she really likes the texture. She loves them so much, we bought a second set and will probably buy a third to have in reserve. (We are realistic and don't expect them to last forever.) All I have to say is "where's spiky ball" and she instantly stops what she is doing and goes on the hunt. A great buy!! (NOTE: It's been almost three months and one is just beginning to show some damage. Given that she plays with them non-stop, they've showed amazing durability. And everyone comments on how clean and beautiful her teeth are. I don't brush them or give her dental treats. So it has to be these balls!!)
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Reviewed in the United States on June 23, 2025
A
Verified Purchase
amanda bragg
West Palm Beach, US
★★★★★ 5
Good sturdy ball for aggressive chewer
Size: 4.5"
Nice heavy duty ball that my 7 yr old pitbull can chew on and not destroy it in 2 minutes. Wish that could get 3 for the cost but whatever. Nice bright colors . Good size that he won't choke on it .
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Reviewed in the United States on March 30, 2026
E
Verified Purchase
Edward Davidson
Chelsea, US
★★★★★ 4
Great ball but poor squeaked design
Size: 4.5"
My Rottie loves these balls. The ball lasts a long time even though he plays hard and chews them. My biggest complaint is the squeaker disconnects easily from inside the ball, the glue does not hold! We have bought many of these balls because eventually the area where the squeaker is attached comes away from the ball leaving an open whole that causes the ball to eventually developed a long crack at which point it no longer is able to be thrown nor is is fun for him any longer.
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Reviewed in the United States on December 19, 2025
A
Verified Purchase
A. Estrella
Chelsea, US
★★★★★ 5
Well made and great fun for our Pittie
Size: 4.5"
My pittie loves these! They are way thicker than others. He has learned how to chew on the spikes. Seems like a good teeth cleaning too. Yes, the squeaker breaks! That is a great thing!! With his active chewing, that sound was driving us crazy after a while.
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Reviewed in the United States on February 19, 2026
D
Verified Purchase
Donald
Whiting, US
★★★★★ 5
"Durable Fun: Pweituoet Heavy Duty Squeaky Dog Balls for Aggressive Chewers"
Size: 4.5"
Product Review: The Pweituoet 4.5” Heavy Duty Squeaky Dog Balls have been a hit with my dog, proving to be both durable and entertaining. Durability: These dog balls are impressively tough. My dog is an aggressive chewer, and most toys don’t last long, but these balls have held up exceptionally well. The heavy-duty material and spiked design are perfect for dogs who love to chew, providing both durability and safety. Entertainment: The built-in squeaker adds an extra layer of fun. It captures my dog’s attention immediately, and the squeak keeps him engaged for longer play sessions. The spikes also make the ball easy for him to grip and carry around. Size: The 4.5” size is ideal for medium to large dogs. It’s large enough to avoid being a choking hazard but still easy for my dog to pick up and play with. The size and weight are just right for games of fetch, too. Value: Given the durability and how much my dog enjoys these balls, they offer great value for the price. They’ve lasted much longer than other toys we’ve tried, making them a worthwhile investment for any dog owner with a tough chewer. Overall Verdict: The Pweituoet Heavy Duty Squeaky Dog Balls are an excellent choice for medium to large dogs, especially those who are aggressive chewers. They’re durable, fun, and well-sized, making them a great addition to your dog’s toy collection. Highly recommended!
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Reviewed in the United States on August 10, 2024

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