SKU: 18782750373

Alexa Fluor® 488 Mouse Anti-Human CD154 Antibody (S-R579)

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Description

Alexa Fluor® 488 Mouse Anti-Human CD154 Antibody (S-R579)Product Specification Host Mouse Antigen CD154 Synonyms CD40 ligand; CD40 L; T cell antigen Gp39; TNF related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40L; TNFSF5; TRAP; CD40LG Location Secreted, Cell membrane Accession P29965 Clone Number S R579 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample PMA and Ionomycin treated human PBMC Purification Protein G Concentration 0. 2 mg ml

Product Specification


Host Mouse
Antigen CD154
Synonyms CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein (TRAP); Tumor necrosis factor ligand superfamily member 5; CD40L; TNFSF5; TRAP; CD40LG
Location Secreted, Cell membrane
Accession P29965
Clone Number S-R579
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample PMA and Ionomycin treated human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD154, also known as CD40 ligand (CD40L) or gp39, is a type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on activated CD4+ T cells and can also be found on other immune cells such as CD8+ T cells, natural killer cells, platelets, dendritic cells, and endothelial cells. CD154 can form a trimeric structure and is crucial for humoral and cellular immunity. Its interaction with CD40, its classical receptor, is essential for B cell activation, proliferation, isotype switching, and germinal center formation. This interaction also plays a significant role in T cell priming and cell-mediated immune responses. In addition to CD40, CD154 can bind to several integrins, including αIIbβ3, α5β1, and αMβ2, which are involved in various inflammatory and immune processes. Abnormal expression of CD154 has been implicated in several autoimmune diseases, such as systemic lupus erythematosus (SLE), where it contributes to the overproduction of autoantibodies and inflammation.

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SKU: 18782750373

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TSmith
Omaha, US
★★★★★ 5
Well made for the money.
Beautiful, and well made front zipper sweater. I purchased 7 for Christmas and the men in my family loved the soft feel of the fabric. They were true to size..
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Reviewed in the United States on January 5, 2026
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Nancy
Birmingham, US
★★★★★ 5
Very good quality heavy knit
Color: Blue, Size: Medium
Very nicely made and good quality. Heavy knit. Much nicer than I expected for the price. Size is true to fit.
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Reviewed in the United States on January 12, 2026
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Alice Garza
Birmingham, US
★★★★★ 5
Very stylish
Color: Khaki, Size: Medium
My husband doesn’t like wearing pullover sweaters because he gets hot after being inside for awhile. This sweater jacket was perfect. It’s stylish and well made. Very comfortable and great price. When I gave him the pkg and reminded me he didn’t like sweaters inside. When he opened it and was pleasantly surprised. Finally he could wear a sweater that was easy to put on and take off. He loved everything about it. I bought more colors and he wears every one of them. Great sweater!
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Reviewed in the United States on February 2, 2026
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Tyler Rice
Belleville, US
★★★★★ 5
Fits Well and Warm
Was very nice and warm
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Reviewed in the United States on April 27, 2026
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Angela K. Lacey
Lowell, US
★★★★★ 5
Great quality
Color: Navy Blue, Size: XX-Large
Well made, but VERR THICK!
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Reviewed in the United States on May 5, 2026

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