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Description
Invivo Anti-Mouse VISTA Recombinant mAbProduct Specification Host Armenian hamster Antigen VISTA Synonyms V type immunoglobulin domain containing suppressor of T cell activation; Platelet receptor Gi24; V set domain containing immunoregulatory receptorImported; V set immunoregulatory receptorImported; Dies1; PD 1H; Vsir Location Cell membrane Accession Q9D659 Clone Number S 3827 Antibody Type Recombinant mAb Application ELISA, in vivo blocking of VISTA signaling, in vitro blocking of VISTA
Product Specification
| Host | Armenian hamster |
| Antigen | VISTA |
| Synonyms | V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; V-set domain-containing immunoregulatory receptorImported; V-set immunoregulatory receptorImported; Dies1; PD-1H; Vsir |
| Location | Cell membrane |
| Accession | Q9D659 |
| Clone Number | S-3827 |
| Antibody Type | Recombinant mAb |
| Application | ELISA, in vivo blocking of VISTA signaling, in vitro blocking of VISTA signaling |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH 7.4, Contains no stabilizers or preservatives |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
VISTA (V-domain Ig suppressor of T-cell activation), also known as B7-H5, PD-1H, C10orf54, Dies1, Gi24 or SISP1, is a type I transmembrane immune-checkpoint protein of the B7-CD28 family that is highly expressed on myeloid and granulocytic cells and at lower levels on CD4+ and CD8+ T cells; it functions both as an inhibitory receptor and as a ligand on antigen-presenting cells to suppress T-cell activation, maintain peripheral tolerance, modulate innate and adaptive anti-tumour immunity, and may additionally regulate embryonic stem-cell differentiation via BMP4 inhibition and stimulate MMP14-mediated MMP2 activation.
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