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Description
Mouse Anti-Human CD271 Antibody (S-2902)Product Specification Host Mouse Antigen CD271 Synonyms Tumor necrosis factor receptor superfamily member 16; Gp80 LNGFR; Low affinity neurotrophin receptor p75NTR; Low affinity nerve growth factor receptor (NGF receptor); Low affinity nerve growth factor receptor p75NGFR; Low affinity nerve growth factor receptor p75NGR; p75 ICD; TNFRSF16; NGFR Location Cytoplasm, Cell membrane, Synapse Accession P08138 Clone Number S 2902 Antibody Type Mouse mAb
Product Specification
| Host | Mouse |
| Antigen | CD271 |
| Synonyms | Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor (NGF receptor); Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; p75 ICD; TNFRSF16; NGFR |
| Location | Cytoplasm, Cell membrane, Synapse |
| Accession | P08138 |
| Clone Number | S-2902 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | SW480 |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
CD271 (also termed p75NTR or NGFR) is a low-affinity neurotrophin receptor that functions as a context-dependent molecular switch, promoting either differentiation and apoptosis in normal tissues or survival, stemness and metastasis in cancers by activating MEK/ERK, RhoA/ROCK and other downstream cascades, and its expression marks therapy-resistant melanoma-initiating cells, drives phenotype switching in cutaneous squamous cell carcinoma, correlates with aggressive disease in medulloblastoma and neurofibromatosis tumors, and orchestrates osteogenic commitment of ectomesenchymal stem cells during craniofacial bone development.
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