Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 30 - Sep 4
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Canine CD64 Mouse mAb (S-1110-15)Product Specification Host Mouse Antigen Canine CD64 Synonyms High affinity IgG Fc gamma receptor 1; FcgammaRI Immunogen Recombinant Protein Location Membrane Accession Q7YQJ5 Clone Number S 1110 15 Antibody Type Mouse mAb Isotype IgG2b,k Application ELISA Reactivity Dg Purification Protein A Concentration 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | Canine CD64 |
| Synonyms | High affinity IgG Fc gamma receptor 1; FcgammaRI |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | Q7YQJ5 |
| Clone Number | S-1110-15 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | ELISA |
| Reactivity | Dg |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Background
CD64, also known as FcγRI, is a high-affinity receptor for the Fc region of IgG antibodies and plays a crucial role in the immune response. It is primarily expressed on monocytes, macrophages, and dendritic cells, and can also be induced on neutrophils with IFN-γ and G-CSF. CD64 is involved in antibody-dependent cellular cytotoxicity (ADCC) and the clearance of immune complexes. The receptor's internalization process is a two-step mechanism: monomeric IgG binding leads to rapid internalization and recycling, while cross-linking causes retention and degradation of immune complexes within the cell. CD64's high affinity for IgG (in the nanomolar range) distinguishes it from other Fcγ receptors and is essential for initiating cellular effector responses even at low IgG concentrations. Structurally, CD64 consists of three extracellular Ig-like domains, a transmembrane region, and a cytoplasmic domain, with unique hinge angles that contribute to its high binding affinity. Recent studies have explored CD64 as a target for immunotherapeutic strategies in chronic inflammatory diseases, leveraging its role in macrophage activation and immune complex handling.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy