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Description
Biotin Rat Anti-Mouse Ly-6C Antibody (S-R523)Product Specification Host Rat Antigen Ly 6C Synonyms Lymphocyte antigen 6C1; Ly 6C1; Ly6c1 Location Cell membrane Accession P0CW02 Clone Number S R523 Antibody Type Rat mAb Isotype IgG2c,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 5 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rat |
| Antigen | Ly-6C |
| Synonyms | Lymphocyte antigen 6C1; Ly-6C1; Ly6c1 |
| Location | Cell membrane |
| Accession | P0CW02 |
| Clone Number | S-R523 |
| Antibody Type | Rat mAb |
| Isotype | IgG2c,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Ms |
Background
Ly-6C is a glycosylphosphatidylinositol-anchored cell-surface protein belonging to the Ly-6/uPAR/α-neurotoxin superfamily, selectively expressed on murine monocyte and T-cell subsets where it serves as a dynamic lineage and activation marker—its high level on pro-inflammatory “classical” monocytes (CD11b⁺Ly-6C^hi) enables their recruitment via CCR2 to inflamed tissues, whereas Ly-6C^lo monocytes patrol vasculature and replenish resident macrophages, and transient up-regulation on CD8⁺ T cells correlates with effector differentiation; structurally it forms a three-finger α-helical bundle that can laterally associate with lipid rafts and signaling partners such as T-cell receptor or integrin complexes to modulate calcium flux, cytokine release, and adhesion, thereby critically steering innate–adaptive immune crosstalk in infections, autoimmunity, and cardiovascular disease.
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