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Description
Biotinylated SLAMF7/CRACC/CD319 Avi&His Tag Protein, HumanProduct Specification Species Human Synonyms CS1UNQ576 PRO1138Novel Ly9SLAM Family Member 7Membrane Protein FOAP 12CD2 Subset 1Protein 19ACD2 Like Receptor Activating Cytotoxic CellsCD2 Like Receptor Activating Cytotoxic Cells19A24 Protein19ACD319 AntigenNovel LY9 (Lymphocyte Antigen 9) Like Protein Accession Q9NQ25 Amino Acid Sequence Ser23 Met226, with C Avi tag and 8*His Expression System HEK293 Molecular Weight 35 45kDa (Reducing) Purity 95% by
Product Specification
| Species | Human |
| Synonyms | CS1，UNQ576/PRO1138，Novel Ly9，SLAM Family Member 7，Membrane Protein FOAP-12，CD2 Subset 1，Protein 19A，CD2-Like Receptor Activating Cytotoxic Cells，CD2-Like Receptor-Activating Cytotoxic Cells，19A24 Protein，19A，CD319 Antigen，Novel LY9 (Lymphocyte Antigen 9) Like Protein |
| Accession | Q9NQ25 |
| Amino Acid Sequence | Ser23-Met226, with C-Avi tag and 8*His |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Veillette, A. (2006) Immunol. Rev. 214:22. 2.Tovar, V. et al. (2002) Immunogenetics 54:394. 3.Murphy, J.J. et al. (2002) Biochem. J. 361:431. |
Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. Mature mouse CRACC consists of a 202 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain, a 21 aa transmembrane segment, and an 88 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function.
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