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Description
Biotin Mouse Anti-Human CD3d Antibody (S-R565)Product Specification Host Mouse Antigen CD3d Synonyms T cell surface glycoprotein CD3 delta chain; T cell receptor T3 delta chain; T3D Location Cell membrane Accession P04234 Clone Number S R565 Antibody Type Mouse mAb Isotype IgG2a Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | CD3d |
| Synonyms | T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; T3D |
| Location | Cell membrane |
| Accession | P04234 |
| Clone Number | S-R565 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD3d, also known as CD3 delta chain, is a protein-coding gene located on chromosome 11q23.3. The protein encoded by CD3D is a single-pass type I membrane protein and is a component of the T-cell receptor (TCR) complex, which is crucial for T-cell development and signaling. It forms part of the CD3 complex along with other subunits like CD3γ, CD3ε, and CD3ζ, and it interacts with either the TCRα/β or TCRγ/δ heterodimer to form the TCR/CD3 complex on the T-cell surface. The CD3d protein is also a target for immunotherapies. For example, bispecific antibodies that target CD3d along with tumor-associated antigens can redirect T cells to attack cancer cells, making it a promising target for cancer immunotherapy.
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4.8 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 5
Love it
Size: 11, Color: Black
Almost the perfect travel shoe. Goes well with both casual and formal attire. Walked like a million steps with this in Japan, SEA, etc. only thing it probably can't do is probably hiking.
Otherwise the leather feels really high quality, and the shoe slips on without much fuss. I'd describe the style as: a dressed-up Converse
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Reviewed in the United States on March 22, 2026
★★★★★ 1
Would not every buy marc Joseph shoes ever
Size: 11 Wide, Color: Black
The marc Joseph shoes did not hold up had a blow out rightside of shoes had the shoes for about two weeks when my wife noticed and say that not good.i buy Cohen shoes and Clarke shoes
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Reviewed in the United States on May 7, 2026
★★★★★ 2
Great shoe, horrible lace design.
Size: 13, Color: White, Size: 13, Color: White
This shoes look great and the materials for the actual shoe feel great. They run a little big that doesn't bother me. Unfortunately, the lace design is horrible. I've now have 2 pairs of these shoes and both times the bottom lace has ripped out of the stitching. The first time was on the 2nd day I wore them, and the replacement pair to those it happened after I walked 20 feet. Both times I've tied a knot in the bottom lace so that I could get through the day. Ideally these laces should be connected together and not attached to the shoe (this is how both of my Skechers Slip-ins are designed). Because I like the rest of the shoe so much I'm buying elastic laces to replace the horrible original laces.
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Reviewed in the United States on March 14, 2025
★★★★★ 5
The "Lazy Professional" Look: Is Hands-Free Luxury Actually Real?
Size: 9.5, Color: Black Napa Leather
Living down here in Florida, my footwear needs are pretty specific. It’s hot, it’s humid, and I spent half my life rushing from the car into work or a meeting. I’ve reached that age where I value efficiency just as much as style—maybe more. I’ve been eyeing the Marc Joseph New York Hands-Free Slip-on Penny Loafers for a while, and after putting them through the wringer, here is the honest truth from someone who just wants to look sharp without the hassle.
The "Just Step-In" Reality
Look, the big selling point here is the "Hands-Free" tech. We’ve all seen the commercials for those athletic slip-ins, but finding that in a legitimate leather penny loafer is a different game. Does it work? Yes, surprisingly well. The heel counter is firm enough that it doesn’t collapse when you slide your foot in, but it doesn’t feel like a piece of plastic digging into your Achilles once you’re in. For those of us who are tired of bending over or hunting for a shoehorn every morning, this is a genuine quality-of-life upgrade.
The Florida Factor: Comfort and Style
The leather is actual calfskin (on most models), which is a must for the Florida heat. Synthetic shoes turn into a sauna within ten minutes, but these breathe reasonably well. The aesthetic is classic—it’s a "professor" shoe through and through. You can wear them with chinos and a blazer for work or throw them on with some nice jeans for a weekend lunch.
Inside, they’ve got a gel heel insert and a padded footbed. It’s not quite "walking on a cloud"—let’s not over-hype it—but it’s a massive step up from the hard, flat soles of traditional dress loafers. I’ve spent four hours on my feet lecturing, and my arches didn’t hate me by the end of the day.
The Sizing Gamble
Here’s where you need to be careful. The consensus from other guys (and my own experience) is that the sizing is a bit of a coin toss. They tend to run a little large and sometimes wide. If you have narrow feet, you might find the sides "gaping" or flaring out when you walk, which kills the sleek look. I’d recommend ordering a half-size down if you’re usually between sizes.
The Breakdown
The Pros:
True Hands-Free: You can actually put these on while holding a coffee and a briefcase. No hands needed.
Legit Materials: The calf leather feels premium and smells like the real deal.
Versatility: Perfectly bridges the gap between a "car shoe" and a formal loafer.
Comfort: The gel insert makes a noticeable difference for long-duration wear.
The Cons:
Sizing Inconsistency: They can run wide, leading to some "heel slip" if you don't get the perfect fit.
Break-in Period: The heel is stiff by design (to allow for the slip-on feature), so expect a day or two of minor stiffness.
Price Point: They aren't cheap, though often on sale.
Value for Money
Are they worth it? If you’re comparing them to high-end Italian brands that cost $500, these are an absolute steal. They look 90% as good for a fraction of the price. However, if you're used to $60 mall shoes, the jump to $150+ might feel steep until you realize you’re paying for the convenience of never having to touch your shoes to put them on. For a daily driver in a professional setting, the value is definitely there.
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Reviewed in the United States on April 10, 2026
★★★★★ 5
Step In Look Good
Size: 11.5, Color: Cognac Napa Leather
I am wearing these shoes as I write this review, and they look and feel great. I have a bit of a disability with drop foot on the right leg and bilateral neuropathy and have been wearing step in shoes for about 10 years. But the first company that introduced leather dress and casual shoes stopped making them and now only makes sport and casual shoes. So I have been searching for some that meet my need for shoes like this and this company has given me three pairs, so far. Easy to get into, comfortable to wear, and good looking. And they take polish very well, too. (Remember how to do that?). We may buy another pair or two in different styles as well.
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Reviewed in the United States on April 26, 2026