SKU: 2027537705

Phospho-TAZ (ser89)/Phospho-YAP (Ser127) Recombinant Rabbit mAb (S-1364-129)

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Description

Phospho-TAZ (ser89)/Phospho-YAP (Ser127) Recombinant Rabbit mAb (S-1364-129)Product Specification Host Rabbit Antigen Phospho TAZ (ser89) Phospho YAP (Ser127) Synonyms WW domain containing transcription regulator protein 1; Transcriptional coactivator with PDZ binding motifImported; TAZ s; WWTR1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession Q9GZV5P46937 Clone Number S 1364 129 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Rt Positive Sample PANC 1, HeLa (treated

Product Specification


Host Rabbit
Antigen Phospho-TAZ (ser89)/Phospho-YAP (Ser127)
Synonyms WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motifImported; TAZ s; WWTR1
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus, Cell membrane
Accession Q9GZV5、P46937
Clone Number S-1364-129
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Rt
Positive Sample PANC-1, HeLa (treated with 100 ng/ml Calyculin A for 30 minutes), C6 (treated with 100 ng/ml Calyculin A for 30 minutes)
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Rt

Background

Phospho-TAZ (Ser89) and Phospho-YAP (Ser127) are the inactivated forms of the transcriptional coactivators TAZ (also known as WWTR1) and YAP (Yes-associated protein), respectively, following phosphorylation at serine residue 89 and serine residue 127, representing the activation state of the Hippo signaling pathway. These two phosphorylation sites are located within the 14-3-3 protein binding regions of TAZ and YAP, respectively. When the upstream kinase cascade (such as MST1/2 and LATS1/2) is activated, LATS1/2 directly phosphorylates YAP at Ser127 and TAZ at Ser89. The phosphorylated YAP/TAZ then bind to 14-3-3 proteins in the cytoplasm, leading to cytoplasmic sequestration and ubiquitin-mediated degradation, thereby preventing their nuclear translocation and transcriptional regulatory functions. The Hippo signaling pathway regulates the phosphorylation status of TAZ and YAP, participating in the control of organ size, tissue homeostasis, cell proliferation, and apoptosis. In various tumors, reduced phosphorylation levels of TAZ/YAP (i.e., enhanced activation) are commonly observed. These phosphorylation sites are typically detected using specific antibodies via methods such as immunoblotting or immunohistochemistry, serving as key molecular markers for assessing Hippo signaling pathway activity and the nuclear translocation status of TAZ/YAP.

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SKU: 2027537705

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