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Description
RRBP1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen RRBP1 Synonyms Ribosome binding protein 1; 180 kDa ribosome receptor homolog (RRp); ES 130 related protein; Ribosome receptor protein; KIAA1398 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q9P2E9 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms Positive Sample Caco 2, HepG2, NIH 3T3 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | RRBP1 |
| Synonyms | Ribosome-binding protein 1; 180 kDa ribosome receptor homolog (RRp); ES/130-related protein; Ribosome receptor protein; KIAA1398 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q9P2E9 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | Caco-2, HepG2, NIH/3T3 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
RRBP1, also known as ribosome-binding protein 1, is a membrane-bound protein located in the endoplasmic reticulum (ER) and is critical for ribosome binding. It plays a role in ER proliferation, secretory pathways, and secretory cell differentiation, as well as mediating ER-microtubule interactions. Alternative splicing of RRBP1 results in protein isoforms with different ribosome-binding affinities and secretory functions. This protein is also implicated in various cancers, such as oral squamous cell carcinoma, cervical squamous cell carcinoma, and colorectal cancer, where its expression is often associated with disease progression and prognosis. Recent studies have shown that RRBP1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking. Additionally, it has been identified as a novel peroxisomal biogenesis factor in human cells.
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