SKU: 21297003283

Alexa Fluor® 700 Mouse Anti-Human CD45RO Antibody (S-R401)

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Description

Alexa Fluor® 700 Mouse Anti-Human CD45RO Antibody (S-R401)Product Specification Host Mouse Antigen CD45RO Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; PTPRC Location Cell membrane, Synapse Accession P08575 Clone Number S R401 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 700 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability &

Product Specification


Host Mouse
Antigen CD45RO
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; PTPRC
Location Cell membrane, Synapse
Accession P08575
Clone Number S-R401
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 700
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD45RO is a transmembrane protein tyrosine phosphatase with a molecular weight of approximately 180-220 kDa, belonging to a splice variant of the leukocyte common antigen CD45 family. It is generated through alternative splicing of the CD45 gene, lacking the exon-encoded A, B, and C regions, thus possessing the smallest extracellular domain among CD45 isoforms. CD45RO is predominantly expressed on memory T cells (including effector memory T cells and central memory T cells), activated T cells, monocytes, and macrophages, serving as a key surface marker for memory T cells. Its intracellular domain contains two highly conserved protein tyrosine phosphatase domains, which regulate the phosphorylation status of Src family kinases (e.g., Lck and Fyn) and play a crucial role in T-cell receptor (TCR) signaling, modulating T-cell activation, proliferation, and immune responses. CD45RO expression is closely associated with pathological processes such as chronic inflammation, autoimmune diseases, and transplant rejection, and it is also an important indicator for assessing T-cell immune function in HIV infection. Given its dynamic expression levels reflecting immune status, CD45RO holds potential value in immune monitoring and disease diagnosis.

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SKU: 21297003283

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4.5 ★★★★★
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K
Verified Purchase
Karen K.
Natrona Heights, US
★★★★★ 3
Not as expected
Size: 6 Inch, Color: Bone
I have been looking for these ever since we got a similar one at Sierras for our 1 1/2 yo Cane Corso. She is brutal on chew toys and the first one from the box store held up well. However, this did not hold up as well and she was done with it in less than a week. Still looking for that perfect toy.
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Reviewed in the United States on May 20, 2026
J
Verified Purchase
Jackie
Natrona Heights, US
★★★★★ 5
More durable than expected.
Size: 5 Inch, Color: Raccoon
I was walking through my front room the other day when I noticed a suspicious spot on the floor. It looked like something I should not touch without gloves. As I got closer, I realized what it was. It’s the ‘guts’ from this toy. My dogs (Pit Bull and German Shorthaired Pointer) were each given one. Both are aggressive chewers with their toys. They ATE the faces off these toys and now play with the felt interior. I’m still trying to figure out how they ate through leather while the felt remained intact. Regardless, they still play with them. Now they are basically semi-fuzzy throw toys we can throw in the house because they don’t leave marks on the wall if our aim is off. Sometimes things work out the way they should. :)
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Reviewed in the United States on March 12, 2026
Z
Verified Purchase
ZC
Port Orchard, US
★★★★★ 4
Great with supervision
Size: 6 Inch, Color: Bone
My dogs LOVE these, but removing a star because these apparently are VERY delicious and they will ingest what they rip off if I don’t supervise; also removing a star for how quick they’re able to tear these up. These are like catnip for dogs, I’ll still buy them!
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Reviewed in the United States on September 13, 2025
P
Verified Purchase
Penny Sinclair
Grantham, US
★★★★★ 1
Don't waste your money!!
Size: 5 Inch, Color: Fox
With in minutes my puppy was pulling on the middle fiber stuff. I was worried he would choke/ingest it so I immediately threw it away just like the money I apparently threw away on this unsafe and misleading chew toy.
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Reviewed in the United States on May 29, 2026
J
Verified Purchase
J-WO
Battle Creek, US
★★★★★ 5
Durable!
Size: 5 Inch, Color: Raccoon
Love these toys/brand! Our Beagle had to have stomach surgery from ratting something he shouldn’t have. Since then we hit this brand of toy because he really can’t destroy it! Great quality and highly recommend for dogs that like to chew!
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Reviewed in the United States on June 8, 2026

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