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Description
Human SLP-76 Protein, His TagProduct Specification Species Human Synonyms Lymphocyte cytosolic protein 2, SH2 domain containing leukocyte protein of 76 kDa, SLP 76 tyrosine phosphoprotein (SLP76), LCP2 Accession Q13094 Amino Acid Sequence Protein sequence (Q13094, Met1 Pro533, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein (SLP76), LCP2 |
| Accession | Q13094 |
| Amino Acid Sequence | Protein sequence (Q13094, Met1-Pro533, with C-His Tag) MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 61.9 kDa Observed MW: 75-100 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Lymphocyte cytosolic protein 2 (LCP2), also commonly known as SLP-76, is a crucial adaptor protein expressed in hematopoietic cells, including T cells, B cells, macrophages, and platelets. It plays a central role in coupling activated immunoreceptors, such as the T-cell receptor (TCR), to multiple downstream signaling pathways. Upon phosphorylation, LCP2 nucleates a large signaling complex that regulates critical cellular processes including proliferation, differentiation, adhesion, and cytokine production. It is essential for proper immune cell development and function. Deficiencies in LCP2 signaling are linked to immunodeficiencies and platelet abnormalities, highlighting its fundamental importance in immunity and hemostasis.
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