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Description
CLEC12A/MICL His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CLEC12A, MICL, CLL 1, CLL1, DCAL2, DCAL 2, CD371 Accession A0A2K5WXQ6 Amino Acid Sequence His32 Ala232, with C terminal His Expression System HEK293 Molecular Weight 35 45kDa (Reducing) Purity >95% by SDS PAGE & RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml
Product Specification
| Species | Cynomolgus |
| Synonyms | CLEC12A, MICL, CLL-1, CLL1, DCAL2, DCAL-2, CD371 |
| Accession | A0A2K5WXQ6 |
| Amino Acid Sequence | His32-Ala232, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa (Reducing) |
| Purity | >95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Lahoud M H. et al. (2009) The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J Immunol. 182(12): 7587-7594. |
Background
Clec12a (also called myeloid inhibitory C-type lectin-like receptor, MICL) was originally described as an ITIM-containing inhibitory CLR expressed by human granulocytes and monocytes. It was suggested that Clec12a recognizes some endogenous ligands as soluble Clec12a could bind to single-cell suspensions isolated from various murine tissues. CLEC12A is a myeloid lineage antigen that is highly expressed by AML cells and LSCs, but not expressed by normal hematopoietic stem cells (HSCs), thus minimizing off-target toxicity.
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