SKU: 22271087252

STUP1/CHIP His Tag Protein, Human

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Description

STUP1/CHIP His Tag Protein, HumanProduct Specification Species Human Synonyms CHIP, PP1131, STUB1, E3 ubiquitin protein ligase CHIP, Antigen NY CO 7 Accession Q9UNE7 Amino Acid Sequence Ser23 Tyr303 with His Tag at the N Terminus Expression System E. coli Molecular Weight 33 43kDa (Reducing) Purity 95% by SDS PAGE,> 90% by HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 50mM Tris, 150mM NaCl, pH7. 5, 1mM DTT, 10%Glycerol Stability & Storage Stable

Product Specification


Species Human
Synonyms CHIP, PP1131, STUB1, E3 ubiquitin-protein ligase CHIP, Antigen NY-CO-7
Accession Q9UNE7
Amino Acid Sequence

Ser23-Tyr303 with His Tag at the N-Terminus
Expression System E.coli
Molecular Weight

33-43kDa (Reducing)
Purity ＞95% by SDS-PAGE,> 90% by HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Liquid
Storage Buffer

50mM Tris, 150mM NaCl, pH7.5, 1mM DTT, 10%Glycerol
Stability & Storage

Stable for 12 months upon stored at -80℃ from the date of receipt. 

And avoid repeated freeze-thaws cycles.
Reference

1. Ballinger, C.A., et al. (1999). Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Molecular and Cellular Biology, 19(6), 4535-4545.
2. Jiang, J., et al. (2001). CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. Journal of Biological Chemistry, 276(46), 42938-42944.

Background

STUB1 (STIP1 Homology and U-Box Containing Protein 1), commonly known as CHIP (C-terminus of Hsc70 Interacting Protein), is a crucial dual-function protein in cellular proteostasis. It serves as both a co-chaperone and an E3 ubiquitin ligase. As a co-chaperone, it binds to the molecular chaperones Hsp70/Hsc70 and Hsp90 via its N-terminal tetratricopeptide repeat (TPR) domain, assisting in client protein folding and stabilization. Its central role lies in its C-terminal U-box domain, which confers E3 ubiquitin ligase activity. This unique combination allows CHIP to ubiquitinate misfolded or damaged client proteins that are delivered by the chaperones, thereby targeting them for proteasomal degradation. It is a central component of the Protein Quality Control (PQC) system, clearing toxic protein aggregates and maintaining proteome integrity.Dysregulation of CHIP function is linked to various human diseases. Loss-of-function mutations or reduced expression are associated with neurodegenerative disorders (e.g., spinocerebellar ataxia, Alzheimer's, Parkinson's) due to defective clearance of pathogenic proteins like tau and α-synuclein. Conversely, its role in degrading oncogenic clients (e.g., HER2, c-Myc) positions it as a potential tumor suppressor in certain cancers. It also plays key roles in aging, cardiac function, and immune responses, making it a significant therapeutic target.
Shipping Notes
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Exchange/Return Notes
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SKU: 22271087252

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Whiting, US
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Reviewed in the United States on May 17, 2026
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Nice suit great
Really nice suit for the price! Color and material were great. Rins true to size.
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Birmingham, US
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The product is good and beautiful
Size: X-Small, Color: Wine Red-2
I really love it. The suit is very beautiful. The design is exactly as in the picture. Great product. The Size is perfect too.Thank you so much. My husband will be so cute on it..🤩 Good Job.
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Fort Morgan, US
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Iced out Blue suit !!!
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Perfect! Buy your normal size.
Size: X-Large, Color: Green -Jacket
I AM BLOWN AWAY! I ordered this and a shirt less than 12 hours ago and they arrived this morning. I was worried because I've never ordered anything that I didn't have to go up 3 sizes but I read the reviews and it seemed like they have finally figured it out! The jacket is amazing and fit like I had it tailor-made. All of the advertising says "slim fit", which I AM NOT. I ordered an XL and I have 44 & 46reg suit jackets. This is the best of the nearly 2500 purchases I have made from Amazon! This brand just needs to shuffle the letters in their name to be I M A G I N E!
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