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Description
Rat Anti-Mouse/Human CD324 Antibody (S-R650)Product Specification Host Rat Antigen CD324 Synonyms Cadherin 1; CAM 120 80; Epithelial cadherin (E cadherinImported); Uvomorulin; CDHE; UVO; CDH1 Location Cytoplasm, Endosome, Cell membrane Accession P12830P09803 Clone Number S R650 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Hu, Ms Positive Sample HT29 Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4
Product Specification
| Host | Rat |
| Antigen | CD324 |
| Synonyms | Cadherin-1; CAM 120/80; Epithelial cadherin (E-cadherinImported); Uvomorulin; CDHE; UVO; CDH1 |
| Location | Cytoplasm, Endosome, Cell membrane |
| Accession | P12830、P09803 |
| Clone Number | S-R650 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu, Ms |
| Positive Sample | HT29 |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu, Ms |
Background
CD324, also known as E-cadherin or cadherin-1, is a calcium-dependent cell adhesion protein that plays a crucial role in maintaining epithelial tissue integrity and regulating cell proliferation, differentiation, and survival. It is a member of the cadherin superfamily and is widely expressed on the cell surface of most epithelial tissues. The extracellular domain of CD324 facilitates homophilic binding between adjacent cells, while its cytoplasmic domain interacts with the actin cytoskeleton through catenins. This protein is essential for epithelial cell cohesion and acts as an invasion suppressor, with its loss often indicating high tumor aggressiveness in cancer.
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