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Description
CD19 Recombinant Rabbit mAb (S-3357)Product Specification Host Rabbit Antigen CD19 Synonyms B lymphocyte antigen CD19; B lymphocyte surface antigen B4; Differentiation antigen CD19; T cell surface antigen Leu 12 Location Cell membrane Accession P15391 Clone Number S 3357 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Ms Positive Sample A20, mouse spleen Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CD19 |
| Synonyms | B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12 |
| Location | Cell membrane |
| Accession | P15391 |
| Clone Number | S-3357 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Ms |
| Positive Sample | A20, mouse spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms |
| IHC-P | 1:1000 | Ms |
| ICC | 1:100 | Ms |
| IF | 1:500 | Ms |
Background
CD19, also known as B-lymphocyte antigen CD19 or B-Lymphocyte Surface Antigen B4, is a 95 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is encoded by the CD19 gene. It is primarily expressed on all B lineage cells, from early pro-B cells to plasma cells, and plays a crucial role in B cell development, activation, and signaling. As a co-receptor, CD19 enhances signaling through the B cell receptor (BCR) complex, lowering the threshold for B cell activation and promoting B cell proliferation and differentiation. It forms a complex with CD21, CD81, and other proteins, which helps in the recognition of antigens tagged with complement and amplifies BCR signaling. CD19 is also a biomarker for B cell-related diseases and a target for immunotherapies, including monoclonal antibodies and CAR-T cell therapies, due to its consistent expression on B cells and B cell malignancies.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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