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Description
TRIM11 Recombinant Rabbit mAb (S-2960-11)Product Specification Host Rabbit Antigen TRIM11 Synonyms E3 ubiquitin protein ligase TRIM11; Protein BIA1; RING finger protein 92; Tripartite motif containing protein 11; RNF92 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q96F44 Clone Number S 2960 11 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample Raji, Jurkat, THP 1, A431, HEK 293 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | TRIM11 |
| Synonyms | E3 ubiquitin-protein ligase TRIM11; Protein BIA1; RING finger protein 92; Tripartite motif-containing protein 11; RNF92 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q96F44 |
| Clone Number | S-2960-11 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | Raji, Jurkat, THP-1, A431, HEK-293 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| ICC | 1:100 | Hu |
Background
TRIM11 is an E3 ubiquitin ligase of the TRIM family that suppresses proteotoxicity by acting as a dual-function chaperone-disaggregase and proteasome activator: it binds misfolded or aggregation-prone proteins such as tau, α-synuclein and Atxn1-82Q, prevents their aggregation, dissolves pre-formed fibrils, and then targets them for SUMOylation and proteasomal degradation by displacing the de-ubiquitinase USP14 from the 26S proteasome, thereby enhancing overall proteolysis; concurrently TRIM11 ubiquitinates and destabilizes specific regulatory proteins (Axin1, PAX6, ARC105, PHOX2B, TBK1, PHLPP1) to modulate Wnt/β-catenin, neurogenesis, TGF-β, IFN-β and AKT signaling, and its expression is up-regulated in many cancers where it drives proliferation, invasion, glycolysis and ferroptosis resistance, while its down-regulation in Alzheimer’s disease contributes to toxic tau accumulation, positioning TRIM11 as a central node linking protein-quality-control, innate immunity and oncogenesis.
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