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Description
Rat Anti-Mouse CD34 Antibody (S-R599)Product Specification Host Rat Antigen CD34 Synonyms Hematopoietic progenitor cell antigen CD34 Location Membrane Accession Q64314 Clone Number S R599 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to
Product Specification
| Host | Rat |
| Antigen | CD34 |
| Synonyms | Hematopoietic progenitor cell antigen CD34 |
| Location | Membrane |
| Accession | Q64314 |
| Clone Number | S-R599 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:100 | Ms |
Background
CD34 is a highly glycosylated type I transmembrane glycoprotein that serves as a key marker for various stem and progenitor cells, particularly hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). It is selectively expressed on the surface of early-stage HSCs, vascular endothelial cells, and some mesenchymal stem cells. Functionally, CD34 plays a crucial role in mediating cell adhesion and homing of HSCs to the bone marrow through interactions with L-selectin. It also helps maintain the undifferentiated state of progenitor cells and supports their proliferation. In clinical applications, CD34 is widely used to isolate and enrich HSCs for bone marrow transplantation and gene therapy. Additionally, its expression in certain cancers, such as leukemia and some solid tumors, makes it a potential biomarker for cancer diagnosis and a target for therapeutic interventions.
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