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Description
CD33 Recombinant Rabbit mAb,PBS Only (SDT-269-171)Product Specification Host Rabbit Antigen CD33 Synonyms PWS44, Myeloid cell surface antigen CD33, Sialic acid binding Ig like lectin 3, Siglec 3, gp67 Immunogen Recombinant Protein Location Membrane Accession P20138 Clone Number SDT 269 171 Antibody Type Recombinant mAb Application WB, IHC P Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | CD33 |
| Synonyms | PWS44, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67 |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P20138 |
| Clone Number | SDT-269-171 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt, 4°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500 |
Background
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. CD33 cae stimulaten be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell.
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Exchange/Return Notes
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