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Description
Biotinylated Fc γ RIIA/CD32a(R167) His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms CD32a, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2 Accession P12318 1 Amino Acid Sequence Ala36 Ile218, with C terminal His and Avi Tag Expression System HEK293 Molecular Weight 30 35kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | CD32a, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2 |
| Accession | P12318-1 |
| Amino Acid Sequence | Ala36-Ile218, with C-terminal His and Avi Tag |
| Expression System | HEK293 |
| Molecular Weight | 30-35kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Benjamin Descours, Gaël Petitjean, José-Luis López-Zaragoza, Timothée Bruel, Raoul Raffel, Christina Psomas, Jacques Reynes, Christine Lacabaratz, Yves Levy, Olivier Schwartz, Jean Daniel Lelievre & Monsef Benkirane: CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses, Nature volume 543, pages564–567 (2017).. |
Background
Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human Fc gamma Rs are classified into three classes: RI (CD64), RII (CD32), and RIII (CD16), which give rise to multiple isoforms (1-3). Fc gamma RI is a high-affinity receptor that binds monomeric IgG, and Fc gamma RII and RIII are low-affinity receptors that bind aggregated or immune complex IgG (IC). The extracellular domain of human Fc gamma RIIA shares approximately 90% amino acid sequence identity with human Fc gamma RIIB and Fc gamma RIIC. Fc gamma RIIA is expressed on many immune cell types: macrophages, neutrophils, eosinophils, platelets, dendritic cells, and Langerhans cells, where inhibitory ITIM receptors may also be co-expressed and co-engaged by specific ligands. Signaling through FcγRIIA leads to the initiation of inflammatory responses (cytolysis, phagocytosis, degranulation, and cytokine production) that can be modulated by signals from inhibitory receptors. The strength of the signal depends on the ratio of activated and inhibitory receptor expression.
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