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Description
α/β-Tubulin Antibody Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Tubulin Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession P07437P68363 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, A431, A549, NIH 3T3, mouse brain, C6, rat brain, COS 7 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | α/β-Tubulin |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | P07437、P68363 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, A431, A549, NIH/3T3, mouse brain, C6, rat brain, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
The α/β-Tubulin heterodimer is the fundamental building block of microtubules. These proteins polymerize in a GTP-dependent manner to form the polarized protofilaments of the microtubule lattice. α-Tubulin typically binds GTP irreversibly, providing structural stability, while the hydrolysis of GTP to GDP on β-Tubulin is the key driver of microtubule dynamic instability—the stochastic switch between phases of growth and rapid disassembly. Both subunits share a highly conserved GTPase domain and interact longitudinally to extend the hollow cylindrical structure. They are essential for critical cellular processes including cell division, ciliary motility, and intracellular transport. The functionality of microtubules is precisely regulated by tubulin expression levels and post-translational modifications, such as acetylation and tyrosination. Consequently, α/β-tubulin is a major target for cancer chemotherapy (e.g., microtubule-targeting agents) and a focal point in neurodegenerative disease research.
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