SKU: 24800001458

TGF-β3 Protein, Human

$108.00 $120.00
Save 10%
No.2 Bestseller on lamcf.fr >

Pay in installments of $30.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Sep 2 - Sep 7

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

TGF-β3 Protein, HumanProduct Specification Species Human Synonyms ARVD; ARVD1; FLJ16571; LDS5; RNHF; TGFB3; TGFbeta 3; TGF beta 3; TGF beta3; TGF beta 3; transforming growth factor beta 3; transforming growth factor, beta 3. Accession P10600 Concentration 0. 2mg ml Amino Acid Sequence Ala301 Ser412 Expression System HEK293 Molecular Weight 12. 7 kDa (monomer). Purity 95% by SDS PAGE Conjugation Unconjugated Tag No Tag Physical Appearance Liquid Storage Buffer Dissolved in

Product Specification


Species Human
Synonyms ARVD; ARVD1; FLJ16571; LDS5; RNHF; TGFB3; TGFbeta 3; TGF-beta 3; TGF-beta3; TGF-beta-3; transforming growth factor beta-3; transforming growth factor, beta 3.
Accession P10600
Concentration 0.2mg/ml
Amino Acid Sequence

Ala301-Ser412
Expression System HEK293
Molecular Weight

12.7 kDa (monomer).
Purity ≥95% by SDS-PAGE
Conjugation Unconjugated
Tag No Tag
Physical Appearance Liquid
Storage Buffer

Dissolved in sterile 20 mM sodium citrate(pH=2.5) buffer . This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Stability & Storage

Avoid repeated freeze-thaw cycles.
It is recommended that the protein be aliquoted for optimal storage. 

12 months from date of receipt, -20 to -70℃ as supplied

Background

TGF-beta 3 (transforming growth factor-beta 3) is a member of a TGF-beta superfamily subgroup that is defined by their structural and functional similarities (1-5). TGF-beta 3 and its closely related proteins, TGF-beta 1 and --beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial--mesenchymal transition (4, 6, 7). The non-redundant biological effects of TGF-beta 3 include involvement in palatogenesis, chondrogenesis, and pulmonary development (1, 2, 7-9). Human TGF--beta 3 cDNA encodes a 412 amino acid (aa) precursor that contains a 20 aa signal peptide and a 392 aa proprotein. The proprotein is processed by a furin-like convertase to generate a 220 aa latency-associated peptide (LAP) and a 112 aa mature TGF--beta 3 (10, 11). Mature human TGF--beta 3 shows 100%, 99%, and 98% aa identity with mouse/dog/horse
, rat, and pig TGF--beta 3, respectively. TGF-beta 3 is secreted as a complex with LAP. This latent form of TGF-beta 3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin-1, and a subset of integrins (12). TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF--beta RI or ALK--1, to modulate transcription through Smad phosphorylation
(13-15). The divergent biological effects exerted by individual TGF-beta isoforms is dependent upon the recruitment of co-receptors (TGF--beta RIII and endoglin) and the subsequent initiation of Smad--dependent or -independent signaling pathways (14, 16, 17).

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 24800001458

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.7 ★★★★★
Based on 23 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
J
Verified Purchase
Jennifer R
Massapequa, US
★★★★★ 5
Love all the books from this author!
Format: Board book
Love this author and all of her books.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 4, 2026
M
Melissa
Dallas, US
★★★★★ 5
Perfect toddler book for teaching big emotions and calm down techniques in a simple, visual way
Format: Board book, Format: Board book
What I received / first impressions: This is a picture book written for toddlers and young children that walks through what big emotions feel like, where you feel them in your body, and what to do when they show up. It is written in a way that is easy for kids to follow along with a parent and includes practical techniques they can actually use in the moment. What I liked: - Perfectly written for young kids: The language and pacing are just right for toddlers to stay engaged and understand without getting lost. - Teaches body awareness around emotions: I love that it helps children recognize where in their body they feel emotions, which is such a foundational skill for emotional regulation. - Covers a full range of emotions: It addresses big feelings that come from both difficult and happy moments, and acknowledges that emotions show up differently for everyone which is an important and inclusive message. - Interactive and easy to practice at home: This is something you can do together as a family, not just read and set aside. The techniques are simple enough for little ones to actually try. - Parent tips included in the back: The added section for parents on how to integrate the techniques into daily life is a thoughtful bonus that makes this more than just a read-aloud. - Great addition alongside other behavior books: We are fans of the Best Behavior series like Teeth Are Not for Biting and Hands Are Not for Hitting and this fits right in alongside those in both tone and approach. What I didn't like / concerns: Nothing. This book delivered exactly what we needed and then some. Who I think this is best for: - Parents of toddlers and young children looking for a practical, visual tool for emotional regulation - Families who already enjoy behavior and feelings books and want to add to their collection - Anyone looking for a book they can actively use with their child rather than just read to them - Teachers or caregivers working with young children on identifying and managing big emotions Bottom line: This book has genuinely helped us work through big emotions at home in a way our child can understand and participate in. It is visual, approachable, and gives both kids and parents real tools to use together. We are so glad we found it and it has earned a permanent spot in our regular reading rotation. Would I buy again? Yes, and would gift it to other parents of young children without hesitation.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 30, 2026
T
Verified Purchase
Tonya
Pawtucket, US
★★★★★ 5
Toddlerhood is a journey you should enjoy
Format: Hardcover, Format: Hardcover
Toddlerhood is a completely different game from the newborn or the curious infant. But it's not just "the terrible twos," or the throw down to the ground tantrums. It's learning and doing so together and finding joy every day. As a single mom, i was looking for parenting advice and books and felt like I was continuously getting let down. I liked a little from a couple of different topics, but it felt like no one was really connecting to what I wanted to represent. I read the book transforming toddlerhood, and was so happy. Not only does the book have great advice, but actual real situation suggestions and free available resources you can download and use. My coparent and I have both read it. We love that you can do sections at a time, the easy and relatable language and small laughs of how on point Devon is. Really the only toddler parenting book you need!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 27, 2025
S
Verified Purchase
Skowwow
Draper, US
★★★★★ 5
Turns Toddler Parenting Struggles into Strengths
Format: Hardcover
We are in the thick of toddlerhood in our house. And I frequently feel at a loss. Ever feel that way? Along comes this book. I’ve followed the author on social media for years and implemented quite a few of her tips. So after one especially rough toddler parenting day, I opened up to JUST the table of contents and felt hope for the first time in a long while. This book can be read as a whole book or you can hit the chapters that are most relevant like “Decoding Screaming, Yelling, and Demands” or “Supporting a Slow-To-Warm Up Child”. Literally feels like Devon has been a fly on the wall at my house. Her writing supports us a parents, helps us understand these toddlers as humans, and gives us bite sized actionable ideas and mindset shifts that work!! I really have felt so much hope and empowerment as I’ve read even just a paragraph at a time. Can’t wait to get through the whole book!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 27, 2025
R
Verified Purchase
Ryan Sharrow
Chelsea, US
★★★★★ 5
Amazing parenting help
Format: Hardcover
Very good book, works like google as you come up against walls while raising children. Just look up the issues you’re having and get practical advice on how to guide your littles for life.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 14, 2026

recommand products

Connected Ring - 3 Bands
50.00
Heart Locket Necklace
127.00
Brett® EDDIE SUN
204.50
Balance Ring
44.00
Brett® ED
285.50