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Description
PSCA Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms UNQ206, PRO232,Prostate stem cell antigen Accession P57096 Amino Acid Sequence Leu21 Asn95, with N terminal Fc Expression System HEK293 Molecular Weight 38 53kDa (Reducing) Purity 95% by SDS PAGE Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after
Product Specification
| Species | Mouse |
| Synonyms | UNQ206, PRO232,Prostate stem cell antigen |
| Accession | P57096 |
| Amino Acid Sequence | Leu21-Asn95, with N-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 38-53kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1735-40. |
Background
Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Mouse PSCA (mPsca) shares 65% homology with human PSCA at the nucleotide and amino acid levels. Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Knockdown of PSCA induced EMT and reduced metastatic potentials of the DU145 cells, suggesting that PSCA played an important role in prostatic carcinogenesis and progression.
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