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Description
CXCL10/IP-10 Recombinant Rabbit mAb (SDT-1910-136)Product Specification Host Rabbit Antigen CXCL10 IP 10 Synonyms 10 kDa interferon gamma induced protein (Gamma IP10; IP 10), Small inducible cytokine B10 Immunogen Recombinant Protein Accession P02778 Clone Number SDT 1910 136 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against GRO alpha, GRO beta, MCP 1 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | CXCL10/IP-10 |
| Synonyms | 10 kDa interferon gamma-induced protein (Gamma-IP10; IP-10), Small-inducible cytokine B10 |
| Immunogen | Recombinant Protein |
| Accession | P02778 |
| Clone Number | SDT-1910-136 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against GRO alpha, GRO beta, MCP-1 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. It exerts its biological effects by binding to the CXCR3 receptor and plays a crucial role in immune responses. CXCL10 is a pleiotropic molecule with diverse functions, including promoting the chemotaxis of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation, and modulating angiogenesis in infectious diseases, inflammation, and cancer. It is primarily produced by various cell types in response to IFN-γ and is involved in activating T lymphocytes, NK cells, macrophages, dendritic cells, and B cells. Elevated levels of CXCL10 are associated with several pathological conditions, such as autoimmune diseases, viral infections, and tumor development.
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