SKU: 25504438106

CLEC9A Recombinant Rabbit mAb (S-1904-154)

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Description

CLEC9A Recombinant Rabbit mAb (S-1904-154)Product Specification Host Rabbit Antigen CLEC9A Synonyms C type lectin domain family 9 member A; CD370 Immunogen Synthetic Peptide Location Membrane Accession Q6UXN8 Clone Number S 1904 154 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage

Product Specification


Host Rabbit
Antigen CLEC9A
Synonyms C-type lectin domain family 9 member A; CD370
Immunogen Synthetic Peptide
Location Membrane
Accession Q6UXN8
Clone Number S-1904-154
Antibody Type Recombinant mAb
Isotype IgG
Application IHC-P, IF
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:2000 Hu
IF 1:100 Hu

Background

CLEC9A (C-type lectin domain family 9 member A), also known as DNGR-1 (Dendritic Cell NK Lectin Group Receptor-1), is a type V C-type lectin-like receptor predominantly expressed on the surface of conventional dendritic cells (cDCs), specifically the CD8α+ subset in mice and CD141+ DCs in humans, as well as plasmacytoid dendritic cells (pDCs). This single-pass transmembrane protein features a C-terminal hemITAM-like signaling motif in its cytoplasmic tail, which enables SYK kinase recruitment and downstream signaling upon ligand engagement. CLEC9A functions as a specialized damage-associated molecular pattern (DAMP) receptor that recognizes filamentous actin (F-actin) exposed by necrotic cells but hidden in viable cells, thereby allowing dendritic cells to detect cell death and initiate immune responses. Upon binding to its ligand, CLEC9A triggers internalization of dead cell material into specialized endosomal compartments, facilitating efficient cross-presentation of necrotic cell-associated antigens to CD8+ T cells and thereby bridging innate recognition of cell injury with adaptive cytotoxic immunity. This unique capability makes CLEC9A crucial for anti-tumor immunity, viral clearance, and tissue homeostasis, while also serving as a promising therapeutic target for vaccine development and cancer immunotherapy through antibody-mediated targeting and adjuvant delivery systems.

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SKU: 25504438106

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Jessica Burdett
Bozeman, US
★★★★★ 5
Best socks!
Size: Medium, Color: Blue
I love these socks! They last for years and they fit so nicely on my feet. I love that I can wear the in tennis shoes or wool boots and they never move!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 21, 2025
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john jeffrey elliott
Dallas, US
★★★★★ 1
TOO SMALL
Size: Medium, Color: Blue
Nice socks, but they are way too small. Says they fit size 6 - 10. I kept 3 ( I wear size 8) and gave 3 to my daughter (size 8.5). We both agreed that they were just too small.
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Reviewed in the United States on May 12, 2026
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Mar Gee
Birmingham, US
★★★★★ 5
Style and comfort
Size: Medium, Color: Black
Exactly what I was looking for. Style and sock thickness and comfort.
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Reviewed in the United States on December 14, 2025
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Amazon Customer
Cuba, US
★★★★★ 5
Comfortable
Size: Medium, Color: Blue
So comfortable! They stay up perfectly love love love
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Reviewed in the United States on December 7, 2025
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Glass
New York, US
★★★★★ 5
I stay on your foot they don’t slip in your shoe
Number of Items: 3, Color: White/Neutral (3-pairs), Size: Medium
This is the only socks I wear Under Armour because they stay in place I wear a size 8, but they’re more comfortable with a large instead of a medium, but I wear both because I have them already and you can pull them to stretch them out a little bit
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Reviewed in the United States on May 12, 2026

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