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Description
GAD65 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen GAD65 Synonyms Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase (GAD 65); Glutamate decarboxylase 65 kDa isoform; GAD2 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession Q05329 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample mouse brain, mouse cerebellum, rat brain, rat cerebellum Purification Immunogen Affinity Concentration
Product Specification
| Host | Rabbit |
| Antigen | GAD65 |
| Synonyms | Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase (GAD-65); Glutamate decarboxylase 65 kDa isoform; GAD2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | Q05329 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse brain, mouse cerebellum, rat brain, rat cerebellum |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
Background
Glutamic acid decarboxylase 65 (GAD65) is an enzyme that synthesizes the inhibitory neurotransmitter γ-aminobutyric acid (GABA) from glutamate, playing a crucial role in the central nervous system. It is one of the two isoforms of glutamic acid decarboxylase, the other being GAD67. GAD65 is particularly notable for its dynamic structure and its role as a major autoantigen in type 1 diabetes (T1D), with autoantibodies against it often present before the clinical onset of the disease. Structurally, GAD65 forms obligate functional dimers and consists of three domains: the N-terminal domain (NTD), the pyridoxal-5'-phosphate (PLP)-binding domain, and the C-terminal domain (CTD). Its catalytic loop (CL) is dynamic, which contrasts with the stable conformation of GAD67's CL.
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