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Description
RORγt Recombinant Mouse mAb (S-4205)Product Specification Host Mouse Antigen RORt Synonyms Nuclear receptor ROR gamma; Nuclear receptor RZR gamma; Nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; Retinoid related orphan receptor gamma; NR1F3; RORG; RZRG; RORC Location Nucleus Accession P51449 Clone Number S 4205 Antibody Type Mouse mAb Isotype IgG2b,k Application WB Reactivity Hu, Ms, Rt Positive Sample mouse thymus, rat thymus Purification Protein A
Product Specification
| Host | Mouse |
| Antigen | RORγt |
| Synonyms | Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; NR1F3; RORG; RZRG; RORC |
| Location | Nucleus |
| Accession | P51449 |
| Clone Number | S-4205 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse thymus, rat thymus |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
RORγt is a DNA-binding transcription factor of the nuclear-receptor superfamily that serves as the master lineage-defining factor for Th17 cells, ILC3s, and other IL-17-producing lymphocytes, where it integrates cholesterol-derived oxysterol signals to drive the transcription of IL-17A/F, IL-22, and related pro-inflammatory genes, thereby orchestrating mucosal host defense against extracellular bacteria and fungi while also controlling circadian gene networks, lymphoid-organ development, and Treg/Th17 balance, making its activity—tunable by small-molecule agonists or inverse agonists—a pivotal rheostat in autoimmune, neoplastic, and infectious disease pathogenesis.
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Exchange/Return Notes
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