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Description
APC-Cy7 Mouse Anti-Human CD11c Antibody (S-R424)Product Specification Host Mouse Antigen CD11c Synonyms Integrin alpha X; CD11 antigen like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11C; ITGAX Location Membrane Accession P20702 Clone Number S R424 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human Peripheral Blood leukocytes Purification Protein G Concentration 0. 2 mg ml Conjugation
Product Specification
| Host | Mouse |
| Antigen | CD11c |
| Synonyms | Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11C; ITGAX |
| Location | Membrane |
| Accession | P20702 |
| Clone Number | S-R424 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD11c is a type I transmembrane protein and a member of the β2 integrin family, primarily expressed on dendritic cells, monocytes, macrophages, neutrophils, and some B cells. It forms a heterodimer with CD18, known as integrin αXβ2. This molecule plays a crucial role in immune cell functions such as adhesion, phagocytosis, and cell migration. CD11c is also involved in the regulation of B cell homeostasis and the development of T cells in the thymus. Additionally, it has been implicated in the clearance of apoptotic cells by microglia during developmental apoptosis.
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