SKU: 26855840995

FGF-19 Recombinant Rabbit mAb,PBS Only (SDT-1070-17)

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Description

FGF-19 Recombinant Rabbit mAb,PBS Only (SDT-1070-17)Product Specification Host Rabbit Antigen FGF 19 Synonyms Fibroblast growth factor 19; FGF19 Immunogen Recombinant Protein Location Secreted Accession O95750 Clone Number SDT 1070 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IP Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt reconstitution,4C as

Product Specification


Host Rabbit
Antigen FGF-19
Synonyms Fibroblast growth factor 19; FGF19
Immunogen Recombinant Protein
Location Secreted
Accession O95750
Clone Number SDT-1070-17
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, IP
Reactivity Hu
Purification Protein A
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS
Stability & Storage

12 months from date of receipt / reconstitution,4°C as supplied

Dilution


application dilution species
WB 1:1000
IHC 1:100
IP 1:50

Background

FGF-19 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. Bile acids bind to the farnesoid X receptor (FXR), stimulating FGF19 transcription. FGF19 regulates new bile acid synthesis, acting through the FGFR4/Klotho-β receptor complexes in the liver to inhibit CYP7A1. FGF19 also has metabolic effects, affecting glucose and lipid metabolism when used in experimental mouse models. Furthermore, FGF19 is frequently amplified in human cancers. Amplification of the FGF19 genomic locus was found in liver cancer, breast cancer, lung cancer, prostate cancer, bladder cancer, and esophageal cancer, among others. Targeting FGF19 inhibits tumor growth in colon cancer cells and hepatocellar carcinoma. Increase in FGF19 correlates with tumor progression and poorer prognosis of hepatocellular carcinoma.

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SKU: 26855840995

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4.7 ★★★★★
Based on 14 reviews
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Product Reviews
L
Verified Purchase
Lee
Chelsea, US
★★★★★ 5
This product work so well it will surpass your expectations it did mine
Size: 1-Pack (32 oz)
This product is well worth the price. I had a small branch puncture a hole through the sidewall of a tire on my 4 wheeler. The hole was at least 3/8” and was done by a tree limb so the edges were jagged. I followed instructions on the product yet the whole time I thought I was wasting my time and the product most likely. I was pleasantly surprised and wrong. It sealed as soon as re inflated the tire and hasn’t leaked down in over 6 months now. I was so impressed I put 2 packs in everything I drive on road and off road.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 21, 2026
K
Verified Purchase
KatAC
Battle Creek, US
★★★★★ 5
Best fix for flats that I've ever used
I have a large zero turn mower that is 10 years old and had a slow leak in the front tire. I tried fix a flat but even a full can would barely get any of the product into the tire and would end up oozing around the valve. After a long search, I found FlatOut. I was reluctant at first because it required removing the valve core, which I had never done. (I'm a 60+ year old female.) But the ratings were so high and the fact it was made with Kevlar, changed my mind. And I am so glad!! The instructions were so simple, core valve came right out (and the tool and new core valve is included), the tube that you pull from the bottle, fit snuggly on the valve stem yet was not difficult to put on. I elevated the bottle, added the amount I thought it needed, removed the tube, pushed it back in the bottle, replaced the cap, and then put the new valve stem back in. It only took a few minutes. And no mess! I had put on rubber gloves, expecting some to spill but it's a thick liquid and does not seep out anywhere it's not supposed to! I filled the tire with air and checked it each day for a week to make sure there was no leak before I used it. I then mowed some rough ground that is hilly and rocky and when I was done, the tire was perfect. I was so pleased I did the same thing to the other tire that never lost any air because I didn't want to wait for a leak. BUY THIS PRODUCT if you are tired of messing with slow leaks or flat tires! I will never use anything else. I purchased a package of core valves and taped them on the bottle so I'll have them when needed! I would give this product 10 stars if I could. It states on the bottle this product was used in the military, so it really has been tested. Thank you FlatOut for a product that actually does what it says!
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Reviewed in the United States on June 15, 2023
G
Verified Purchase
Gabriel
Grantham, US
★★★★★ 5
IT JUST WORKS!
Size: 1-Pack (32 oz), Size: 1-Pack (32 oz)
I recently found a piece of wire stuck in the side wall of my Zero Turn mower's rear tire. The tire has less than a full season of use, so I was looking for an alternative to "FIX" my sidewall puncture instead of removing it and patching or replacing. After looking up several different products, I decided to try Multi Seal. After reading the directions, I removed the valve tool that was included with the bottle. It was a little confusing, but the tool is basically a "stopper" for the clear hose that's in the bottle. Once I removed the valve from the stem, I connected the clear hose to the stem and proceeded to squeeze the product into the tire. I was surprised as to how easily it flowed into the tire. It was much easier than other tire sealants I've used. Although, its recommended to use half of the bottle in a rear tire, I used significantly more. I wanted to make sure the sealant would get to the sidewall. When I was finished adding the product, I replaced the valve in the stem and inflated the tire to the recommended pressure. It was at this time I pulled the wire from the tire. I started the mower and drove it for a few minutes. When i stopped, the product had started to escape the tire through the puncture. In fact, I had another unknown puncture that showed signs of the Multi Seal product. After a few minutes, air was still escaping from the punctures so I ended up driving the mower for about 10-15 minutes. This seemed to do the trick. Over a week later and 1.5 hours of operation later, the tire is still holding air pressure. This product is the BEST tire sealant I have ever used. I will be adding it to all my non-highway tires that I own.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 22, 2019
M
Verified Purchase
MasterTarl
Waukegan, US
★★★★★ 4
Works with effort
Size: 1-Gallon (128 oz)
I was skeptical about buying this. However, after installing the recommended ozs per tire, it seems to have fixed the two flats on my zero-turn lawnmower. I will continue to monitor the pressure, but it's held for four days at the time of this review. Caution. Even with a flat tire and no air, pumping the product into the tire builds backpressure, and the internal two-piece pump shaft blew apart on me; afterward, the hose connecting to the value stem blew off. In short, a lot of fluid was lost. Finally, the bottleneck of the pump collapsed when the bottle was only half empty. It's not as smooth an install as you are led to believe. It is a good concept, but the pump bottle is cheaply made and does not hold up well to deliver all the product to the tires. It fatigues after around 50 - 60 pumps, and you wind up struggling to get the job done.
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Reviewed in the United States on December 31, 2023
F
Verified Purchase
Frances
Dallas, US
★★★★★ 5
It did work
Size: 1-Pack (32 oz)
Sealed a small nail hole in a front tractor tire. Better than taking to shop for inside patch or making the 3x bigger for a rope patch.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 6, 2026

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